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rde-8 RNase NYN domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177483, updated on 2-Nov-2024

Summary

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Official Symbol
rde-8
Official Full Name
RNase NYN domain-containing protein
Primary source
WormBase:WBGene00022620
Locus tag
CELE_ZC477.5
See related
AllianceGenome:WB:WBGene00022620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables RNA endonuclease activity and mRNA binding activity. Involved in siRNA processing. Located in mutator focus. Is expressed in germ line. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rde-8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (7101379..7103261, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene ncRNA Neighboring gene Coiled-coil domain-containing protein 51 Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Disruption of the mutator complex triggers a low penetrance larval arrest phenotype. Rogers AK, et al. MicroPubl Biol, 2020. PMID 32542232, Free PMC Article
  2. GTSF-1 is required for formation of a functional RNA-dependent RNA Polymerase complex in Caenorhabditis elegans. Almeida MV, et al. EMBO J, 2018 Jun 15. PMID 29769402, Free PMC Article
  3. A ribonuclease coordinates siRNA amplification and mRNA cleavage during RNAi. Tsai HY, et al. Cell, 2015 Jan 29. PMID 25635455, Free PMC Article
  4. A tudor domain protein, SIMR-1, promotes siRNA production at piRNA-targeted mRNAs in C. elegans. Manage KI, et al. Elife, 2020 Apr 27. PMID 32338603, Free PMC Article
  5. Distinct regions of the intrinsically disordered protein MUT-16 mediate assembly of a small RNA amplification complex and promote phase separation of Mutator foci. Uebel CJ, et al. PLoS Genet, 2018 Jul. PMID 30036386, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA endonuclease activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in siRNA processing IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasmic ribonucleoprotein granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mutator focus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
RNase NYN domain-containing protein
NP_501107.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7101379..7103261 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068706.6 → NP_501107.1  RNase NYN domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501107.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23342
    Conserved Domains (1) summary
    pfam11977
    Location:69 → 216
    RNase_Zc3h12a; Zc3h12a-like Ribonuclease NYN domain
Nucleotide Protein
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