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rpc-1 DNA-directed RNA polymerase subunit [ Caenorhabditis elegans ]

Gene ID: 177491, updated on 2-Nov-2024

Summary

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Official Symbol
rpc-1
Official Full Name
DNA-directed RNA polymerase subunit
Primary source
WormBase:WBGene00004411
Locus tag
CELE_C42D4.8
See related
AllianceGenome:WB:WBGene00004411
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity and DNA-directed 5'-3' RNA polymerase activity. Predicted to contribute to RNA polymerase III activity. Predicted to be involved in transcription by RNA polymerase III. Predicted to be located in nuclear lumen. Predicted to be part of RNA polymerase III complex. Human ortholog(s) of this gene implicated in Wiedemann-Rautenstrauch syndrome and hypomyelinating leukodystrophy 7. Orthologous to human POLR3A (RNA polymerase III subunit A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See rpc-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (7160135..7165748, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MSP domain-containing protein Neighboring gene Serine/threonine-protein phosphatase Neighboring gene Protein maph-9 Neighboring gene Uncharacterized protein Neighboring gene Skp1-related protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Molecular cloning and sequencing of ama-1, the gene encoding the largest subunit of Caenorhabditis elegans RNA polymerase II. Bird DM, et al. Mol Cell Biol, 1989 Oct. PMID 2586513, Free PMC Article
  2. Integral nuclear pore proteins bind to Pol III-transcribed genes and are required for Pol III transcript processing in C. elegans. Ikegami K, et al. Mol Cell, 2013 Sep 26. PMID 24011592, Free PMC Article
  3. RNA polymerase III limits longevity downstream of TORC1. Filer D, et al. Nature, 2017 Dec 14. PMID 29186112, Free PMC Article
  4. A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. Held JP, et al. Elife, 2022 Apr 22. PMID 35451962, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to RNA polymerase III activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in transcription by RNA polymerase III IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
  
part_of RNA polymerase III complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear lumen IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DNA-directed RNA polymerase subunit
NP_501127.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7160135..7165748 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068726.5 → NP_501127.2  DNA-directed RNA polymerase subunit [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501127.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18566
    Conserved Domains (4) summary
    cd02736
    Location:1034 → 1374
    RNAP_III_Rpc1_C; Largest subunit (Rpc1) of Eukaryotic RNA polymerase III (RNAP III), C-terminal domain
    PRK04309
    Location:1019 → 1383
    PRK04309; DNA-directed RNA polymerase subunit A''; Validated
    PRK08566
    Location:14 → 923
    PRK08566; DNA-directed RNA polymerase subunit A'; Validated
    cd02583
    Location:26 → 887
    RNAP_III_RPC1_N; Largest subunit (RPC1) of eukaryotic RNA polymerase III (RNAP III), N-terminal domain
Nucleotide Protein
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