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kcc-1 K+/Cl-Cotransporter;Solute carrier family 12 member 6 [ Caenorhabditis elegans ]

Gene ID: 177495, updated on 2-Nov-2024

Summary

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Official Symbol
kcc-1
Official Full Name
K+/Cl-Cotransporter;Solute carrier family 12 member 6
Primary source
WormBase:WBGene00006504
Locus tag
CELE_R13A1.2
See related
AllianceGenome:WB:WBGene00006504
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables potassium:chloride symporter activity. Involved in chloride transmembrane transport and potassium ion transmembrane transport. Predicted to be located in membrane and synapse. Predicted to be active in plasma membrane. Is expressed in several structures, including hermaphrodite distal tip cell; pharyngeal muscle cell; tail neurons; ventral nerve cord; and vulva. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See kcc-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (7206269..7218002)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Degenerin unc-8 Neighboring gene ncRNA Neighboring gene BTB domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Globin domain-containing protein Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter. Zimanyi CM, et al. Structure, 2020 Sep 1. PMID 32679039, Free PMC Article
  2. Cloning, characterization, and gene organization of K-Cl cotransporter from pig and human kidney and C. elegans. Holtzman EJ, et al. Am J Physiol, 1998 Oct. PMID 9755127
  3. The potassium chloride cotransporter KCC-2 coordinates development of inhibitory neurotransmission and synapse structure in Caenorhabditis elegans. Tanis JE, et al. J Neurosci, 2009 Aug 12. PMID 19675228, Free PMC Article
  4. Glial regulators of ions and solutes required for specific chemosensory functions in Caenorhabditis elegans. Wang L, et al. iScience, 2022 Dec 22. PMID 36567707, Free PMC Article
  5. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.
    Title: Structure of the Regulatory Cytosolic Domain of a Eukaryotic Potassium-Chloride Cotransporter.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride:monoatomic cation symporter activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium:chloride symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium:chloride symporter activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chloride transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
K+/Cl-Cotransporter;Solute carrier family 12 member 6
NP_001293846.1
  • Confirmed by transcript evidence
NP_001293847.1
  • Confirmed by transcript evidence
NP_001293848.1
  • Confirmed by transcript evidence
NP_001294072.1
  • Confirmed by transcript evidence
NP_001368174.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7206269..7218002
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001306917.3 → NP_001293846.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293846.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FWN4
    Conserved Domains (2) summary
    TIGR00930
    Location:166 → 1153
    2a30; K-Cl cotransporter
    pfam03522
    Location:776 → 1153
    SLC12; Solute carrier family 12

  2. NM_001306918.3 → NP_001293847.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293847.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6F510
    Conserved Domains (2) summary
    TIGR00930
    Location:108 → 1095
    2a30; K-Cl cotransporter
    pfam03522
    Location:718 → 1095
    SLC12; Solute carrier family 12

  3. NM_001306919.3 → NP_001293848.1  Solute carrier family 12 member 6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293848.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FCX2
    Conserved Domains (2) summary
    TIGR00930
    Location:76 → 1063
    2a30; K-Cl cotransporter
    pfam03522
    Location:686 → 1063
    SLC12; Solute carrier family 12

  4. NM_001307143.2 → NP_001294072.1  K+/Cl-Cotransporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294072.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NV09
    Conserved Domains (2) summary
    TIGR00930
    Location:121 → 1108
    2a30; K-Cl cotransporter
    pfam03522
    Location:731 → 1108
    SLC12; Solute carrier family 12

  5. NM_001380315.1 → NP_001368174.1  Solute carrier family 12 member 6 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    N1NVB5
    Conserved Domains (1) summary
    TIGR00930
    Location:45 → 1032
    2a30; K-Cl cotransporter
Nucleotide Protein
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