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cap-1 F-actin-capping protein subunit alpha [ Caenorhabditis elegans ]

Gene ID: 177497, updated on 2-Nov-2024

Summary

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Official Symbol
cap-1
Official Full Name
F-actin-capping protein subunit alpha
Primary source
WormBase:WBGene00000292
Locus tag
CELE_D2024.6
See related
AllianceGenome:WB:WBGene00000292
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable actin filament binding activity. Predicted to be involved in actin cytoskeleton organization and barbed-end actin filament capping. Part of dynactin complex. Is expressed in several structures, including germ line; nervous system; rectal valve cell; spermatheca; and vulva. Orthologous to several human genes including CAPZA1 (capping actin protein of muscle Z-line subunit alpha 1) and CAPZA2 (capping actin protein of muscle Z-line subunit alpha 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cap-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (7228422..7230223, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene F-box domain-containing protein Neighboring gene Mid2 domain-containing protein Neighboring gene DUF19 domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of functional residues on Caenorhabditis elegans actin-interacting protein 1 (UNC-78) for disassembly of actin depolymerizing factor/cofilin-bound actin filaments. Mohri K, et al. J Biol Chem, 2004 Jul 23. PMID 15150269
  2. The alpha and beta subunits of nematode actin capping protein function in yeast. Waddle JA, et al. Mol Biol Cell, 1993 Sep. PMID 8257793, Free PMC Article
  3. Establishment of initial asymmetry in early Caenorhabditis elegans embryos. Priess JR. Curr Opin Genet Dev, 1994 Aug. PMID 7950325
  4. Architecture of the cortical actomyosin network driving apical constriction in C. elegans. Zhang P, et al. J Cell Biol, 2023 Sep 4. PMID 37351566, Free PMC Article
  5. Caenorhabditis elegans ortholog of the p24/p22 subunit, DNC-3, is essential for the formation of the dynactin complex by bridging DNC-1/p150(Glued) and DNC-2/dynamitin. Terasawa M, et al. Genes Cells, 2010 Nov. PMID 20964796, Free PMC Article

See all (19) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables actin filament binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in actin filament capping IEA
Inferred from Electronic Annotation
more info
  
involved_in barbed-end actin filament capping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in barbed-end actin filament capping IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of F-actin capping protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of F-actin capping protein complex IEA
Inferred from Electronic Annotation
more info
  
located_in actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
is_active_in cortical cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of dynactin complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of protein-containing complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
F-actin-capping protein subunit alpha
NP_501145.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7228422..7230223 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068744.6 → NP_501145.1  F-actin-capping protein subunit alpha [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501145.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P34685
    Conserved Domains (1) summary
    pfam01267
    Location:10 → 280
    F-actin_cap_A; F-actin capping protein alpha subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P34685.1

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