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cec-4 Chromo domain-containing protein cec-4 [ Caenorhabditis elegans ]

Gene ID: 177536, updated on 2-Nov-2024

Summary

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Official Symbol
cec-4
Official Full Name
Chromo domain-containing protein cec-4
Primary source
WormBase:WBGene00017990
Locus tag
CELE_F32E10.2
See related
AllianceGenome:WB:WBGene00017990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables methylated histone binding activity. Involved in chromosome attachment to the nuclear envelope; regulation of cell differentiation; and regulation of gene expression. Located in nuclear inner membrane. Is expressed in germ cell and somatic cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cec-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (7576181..7577325)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C-type lectin domain-containing protein 180 Neighboring gene ncRNA Neighboring gene Tudor domain-containing protein Neighboring gene Chromo domain-containing protein Neighboring gene NUC153 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Histone H3K9 methylation promotes formation of genome compartments in Caenorhabditis elegans via chromosome compaction and perinuclear anchoring. Bian Q, et al. Proc Natl Acad Sci U S A, 2020 May 26. PMID 32385148, Free PMC Article
  2. Lamina-Dependent Stretching and Unconventional Chromosome Compartments in Early C. elegans Embryos. Sawh AN, et al. Mol Cell, 2020 Apr 2. PMID 32105612, Free PMC Article
  3. Alternative somatic and germline gene-regulatory strategies during starvation-induced developmental arrest. Webster AK, et al. Cell Rep, 2022 Oct 11. PMID 36223742, Free PMC Article
  4. Mechanism of chromatin segregation to the nuclear periphery in C. elegans embryos. Gonzalez-Sandoval A, et al. Worm, 2016. PMID 27695653, Free PMC Article
  5. Active chromatin marks drive spatial sequestration of heterochromatin in C. elegans nuclei. Cabianca DS, et al. Nature, 2019 May. PMID 31118512

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The coupling of the LMN-Y59C mutation with the ablation of CEC-4, a chromodomain protein that anchors H3K9-methylated chromatin at the nuclear envelope (NE), suppressed the muscle-associated disease phenotypes
    Title: Loss of an H3K9me anchor rescues laminopathy-linked changes in nuclear organization and muscle function in an Emery-Dreifuss muscular dystrophy model.
  2. In a screen for perinuclear anchors of heterochromatin, study identified a previously uncharacterized C. elegans chromodomain protein, CEC-4; CEC-4 binds to mono-, di-, or tri-methylated H3K9 and localizes at the nuclear envelope independently of H3K9 methylation and nuclear lamin.CEC-4 is necessary for heterochromatin anchoring, but not for transcriptional repression.
    Title: Perinuclear Anchoring of H3K9-Methylated Chromatin Stabilizes Induced Cell Fate in C. elegans Embryos.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables methylated histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methylated histone binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables methylated histone binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chromosome attachment to the nuclear envelope IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromosome attachment to the nuclear envelope IEA
Inferred from Electronic Annotation
more info
  
involved_in chromosome attachment to the nuclear envelope IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nuclear inner membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear inner membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chromo domain-containing protein cec-4
NP_501231.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7576181..7577325
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068830.10 → NP_501231.1  Chromo domain-containing protein cec-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501231.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19972
    UniProtKB/TrEMBL
    A0A1B4Z3W4
    Conserved Domains (1) summary
    smart00298
    Location:86 → 140
    CHROMO; Chromatin organization modifier domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19972.1

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