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klo-1 Glycoside hydrolase family 1 protein [ Caenorhabditis elegans ]

Gene ID: 177557, updated on 2-Nov-2024

Summary

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Official Symbol
klo-1
Official Full Name
Glycoside hydrolase family 1 protein
Primary source
WormBase:WBGene00016848
Locus tag
CELE_C50F7.10
See related
AllianceGenome:WB:WBGene00016848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable beta-glucosidase activity. Predicted to be involved in carbohydrate metabolic process. Is expressed in excretory cell and intestine. Used to study kidney disease. Human ortholog(s) of this gene implicated in coronary artery disease; intracranial embolism; and spondylosis. Orthologous to several human genes including GBA3 (glucosylceramidase beta 3 (gene/pseudogene)) and LCTL (lactase like). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See klo-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
8
Sequence:
Chromosome: IV; NC_003282.8 (7745979..7748071, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene PDZ domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Basic proline-rich protein-like Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Peroxidase Neighboring gene ncRNA Neighboring gene Cuticle collagen 14;Nematode cuticle collagen N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deglycosylation is a key step in biotransformation and lifespan effects of quercetin-3-O-glucoside in Caenorhabditis elegans. Dueñas M, et al. Pharmacol Res, 2013 Oct. PMID 23856528
  2. The cooperation of FGF receptor and Klotho is involved in excretory canal development and regulation of metabolic homeostasis in Caenorhabditis elegans. Polanska UM, et al. J Biol Chem, 2011 Feb 18. PMID 21177529, Free PMC Article
  3. KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism. Xu C, et al. EMBO Mol Med, 2017 Oct. PMID 28754744, Free PMC Article
  4. A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans. Tang J, et al. Biochem Biophys Res Commun, 2021 Jul 12. PMID 34034091
  5. FGF23 signalling and physiology. Ho BB, et al. J Mol Endocrinol, 2021 Feb. PMID 33338030, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans.
    Title: A conserved klo-1-mpk-1 pathway regulates autophagy and modulates longevity in Caenorhabditis elegans.
  2. findings indicate that a predicted KL1 isoform of Klotho requires the FGF signalling pathway to crosstalk with the Daf-2/insulin/Igf-like pathway, in order to regulate aging and oxidative stress resistance
    Title: Klotho interferes with a novel FGF-signalling pathway and insulin/Igf-like signalling to improve longevity and stress resistance in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables beta-glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, hydrolyzing O-glycosyl compounds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Glycoside hydrolase family 1 protein
NP_501271.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7745979..7748071 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068870.7 → NP_501271.1  Glycoside hydrolase family 1 protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501271.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18758
    Conserved Domains (1) summary
    cl23725
    Location:7 → 470
    Glyco_hydro_1; Glycosyl hydrolase family 1
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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