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col-14 Cuticle collagen 14;Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177559, updated on 2-Nov-2024

Summary

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Official Symbol
col-14
Official Full Name
Cuticle collagen 14;Nematode cuticle collagen N-terminal domain-containing protein
Primary source
WormBase:WBGene00000603
Locus tag
CELE_C46A5.3
See related
AllianceGenome:WB:WBGene00000603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Human ortholog(s) of this gene implicated in Stickler syndrome; multiple epiphyseal dysplasia 6; and osteochondrodysplasia. Orthologous to human COL9A1 (collagen type IX alpha 1 chain). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See col-14 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (7753408..7754656)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Glycoside hydrolase family 1 protein Neighboring gene Peroxidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Differential modification of the C. elegans proteome in response to acute and chronic gamma radiation: Link with reproduction decline. Dubois C, et al. Sci Total Environ, 2019 Aug 1. PMID 31055208
  2. Sequence comparisons of developmentally regulated collagen genes of Caenorhabditis elegans. Cox GN, et al. Gene, 1989. PMID 2753356
  3. Domain organization and intron positions in Caenorhabditis elegans collagen genes: the 54-bp module hypothesis revisited. Fields C. J Mol Evol, 1988 Dec-1989 Feb. PMID 3148742
  4. Temporal reiteration of a precise gene expression pattern during nematode development. Johnstone IL, et al. EMBO J, 1996 Jul 15. PMID 8670866, Free PMC Article
  5. Identification, sequence and expression patterns of the Caenorhabditis elegans col-36 and col-40 collagen-encoding genes. Levy AD, et al. Gene, 1993 Dec 31. PMID 8299960

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
enables structural constituent of cuticle NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in collagen and cuticulin-based cuticle development NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in extracellular region NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cuticle collagen 14;Nematode cuticle collagen N-terminal domain-containing protein
NP_001040923.1
  • Partially confirmed by transcript evidence
NP_001040924.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7753408..7754656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047458.7 → NP_001040923.1  Cuticle collagen 14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040923.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18834, Q18648
    Conserved Domains (1) summary
    smart01088
    Location:32 → 83
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain

  2. NM_001047459.3 → NP_001040924.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001040924.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B2MZB1
    Conserved Domains (1) summary
    smart01088
    Location:13 → 64
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18834.2

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