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flp-10 FMRF-Like Peptide [ Caenorhabditis elegans ]

Gene ID: 177574, updated on 2-Nov-2024

Summary

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Official Symbol
flp-10
Official Full Name
FMRF-Like Peptide
Primary source
WormBase:WBGene00001453
Locus tag
CELE_T06C10.4
See related
AllianceGenome:WB:WBGene00001453
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in negative regulation of egg-laying behavior; negative regulation of turning behavior involved in mating; and thigmotaxis. Is expressed in nerve ring; neurons; and vulD. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See flp-10 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_003282.8 (7868907..7870081)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene MADF domain-containing protein;WH2 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein kinase Neighboring gene Tyrosine-protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FMRFamide-related peptides (FaRPs) in nematodes: occurrence and neuromuscular physiology. Maule AG, et al. Parasitology, 1996. PMID 9051931
  2. A competition mechanism for a homeotic neuron identity transformation in C. elegans. Gordon PM, et al. Dev Cell, 2015 Jul 27. PMID 26096732, Free PMC Article
  3. FMRFamide neuropeptides and acetylcholine synergistically inhibit egg-laying by C. elegans. Ringstad N, et al. Nat Neurosci, 2008 Oct. PMID 18806786, Free PMC Article
  4. FMRFamide-like peptides expand the behavioral repertoire of a densely connected nervous system. Lee JS, et al. Proc Natl Acad Sci U S A, 2017 Dec 12. PMID 29167374, Free PMC Article
  5. Functional characterization of the putative orphan neuropeptide G-protein coupled receptor C26F1.6 in Caenorhabditis elegans. Mertens I, et al. FEBS Lett, 2004 Aug 27. PMID 15327975

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. flp-10 is required for the sensory transduction involved in male turning behavior.
    Title: FMRFamide-like neuropeptides and mechanosensory touch receptor neurons regulate male sexual turning behavior in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in negative regulation of egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of turning behavior involved in mating IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in thigmotaxis IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
FMRF-Like Peptide
NP_501306.1
  • Product from WormBase gene class flp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7868907..7870081
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068905.6 → NP_501306.1  FMRF-Like Peptide [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501306.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF22
Nucleotide Protein
Heading Accession and Version

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