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atic-1 Bifunctional purine biosynthesis protein ATIC;Phosphoribosylaminoimidazolecarboxamide formyltransferase [ Caenorhabditis elegans ]

Gene ID: 177576, updated on 2-Nov-2024

Summary

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Official Symbol
atic-1
Official Full Name
Bifunctional purine biosynthesis protein ATIC;Phosphoribosylaminoimidazolecarboxamide formyltransferase
Primary source
WormBase:WBGene00016957
Locus tag
CELE_C55F2.1
See related
AllianceGenome:WB:WBGene00016957
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable IMP cyclohydrolase activity and phosphoribosylaminoimidazolecarboxamide formyltransferase activity. Predicted to be involved in 'de novo' IMP biosynthetic process. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in purine-pyrimidine metabolic disorder. Orthologous to human ATIC (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See atic-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
20
Sequence:
Chromosome: IV; NC_003282.8 (7882026..7900257)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Serpentine Receptor, class T Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene lysozyme Neighboring gene Actin-related protein 10 Neighboring gene Cortactin-binding protein-2 N-terminal domain-containing protein Neighboring gene C3HC-type domain-containing protein Neighboring gene CCR4-NOT transcription complex subunit 4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans. Riedinger C, et al. J Biol Chem, 2018 Mar 30. PMID 29414769, Free PMC Article
  2. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article
  3. Exploring transcriptional conservation between Ancylostoma caninum and Haemonchus contortus by oligonucleotide microarray and bioinformatic analyses. Cantacessi C, et al. Mol Cell Probes, 2009 Feb. PMID 18977290
  4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
  5. Transcriptomics of ivermectin response in Caenorhabditis elegans: Integrating abamectin quantitative trait loci and comparison to the Ivermectin-exposed DA1316 strain. Dube F, et al. PLoS One, 2023. PMID 37141255, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. atic-1 is involved in glucotoxic effects under HG conditions, either by blocked atic-1 expression or via AICAR and AMPK induction.
    Title: High-glucose toxicity is mediated by AICAR-transformylase/IMP cyclohydrolase and mitigated by AMP-activated protein kinase in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables IMP cyclohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables IMP cyclohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphoribosylaminoimidazolecarboxamide formyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' IMP biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in 'de novo' IMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in purine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Bifunctional purine biosynthesis protein ATIC;Phosphoribosylaminoimidazolecarboxamide formyltransferase
NP_001023101.2
  • Partially confirmed by transcript evidence
NP_001367679.1
  • Partially confirmed by transcript evidence
NP_741452.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7882026..7900257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380345.3 → NP_001367679.1  Phosphoribosylaminoimidazolecarboxamide formyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QQ5
    Conserved Domains (1) summary
    cl29462
    Location:1 → 386
    AICARFT_IMPCHas; AICARFT/IMPCHase bienzyme

  2. NM_171912.7 → NP_741452.2  Bifunctional purine biosynthesis protein ATIC [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741452.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95QQ4
    Conserved Domains (1) summary
    COG0138
    Location:8 → 594
    PurH; AICAR transformylase/IMP cyclohydrolase PurH [Nucleotide transport and metabolism]

  3. NM_001027930.5 → NP_001023101.2  Phosphoribosylaminoimidazolecarboxamide formyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023101.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JNV5
    Conserved Domains (1) summary
    cl29462
    Location:73 → 464
    AICARFT_IMPCHas; AICARFT/IMPCHase bienzyme
Nucleotide Protein
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