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xpo-3 Exportin-T [ Caenorhabditis elegans ]

Gene ID: 177581, updated on 2-Nov-2024

Summary

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Official Symbol
xpo-3
Official Full Name
Exportin-T
Primary source
WormBase:WBGene00002080
Locus tag
CELE_C49H3.10
See related
AllianceGenome:WB:WBGene00002080
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable tRNA binding activity. Predicted to be involved in tRNA re-export from nucleus. Predicted to be located in nucleus. Predicted to be part of nuclear pore. Predicted to be active in cytoplasm and nuclear matrix. Is expressed in intestine and nervous system. Orthologous to human XPOT (exportin for tRNA). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See xpo-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (7916689..7924032, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cortactin-binding protein-2 N-terminal domain-containing protein Neighboring gene C3HC-type domain-containing protein Neighboring gene CCR4-NOT transcription complex subunit 4 Neighboring gene Sm domain-containing protein Neighboring gene BPTI/Kunitz inhibitor domain-containing protein Neighboring gene ncRNA Neighboring gene UPF0642 protein YBL028C

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evolutionary and transcriptional analysis of karyopherin beta superfamily proteins. Quan Y, et al. Mol Cell Proteomics, 2008 Jul. PMID 18353765, Free PMC Article
  2. Coordinate Regulation of Ribosome and tRNA Biogenesis Controls Hypoxic Injury and Translation. Itani OA, et al. Curr Biol, 2021 Jan 11. PMID 33157031, Free PMC Article
  3. Ran GTPase cycle and importins alpha and beta are essential for spindle formation and nuclear envelope assembly in living Caenorhabditis elegans embryos. Askjaer P, et al. Mol Biol Cell, 2002 Dec. PMID 12475958, Free PMC Article
  4. A tRNA processing enzyme is a key regulator of the mitochondrial unfolded protein response. Held JP, et al. Elife, 2022 Apr 22. PMID 35451962, Free PMC Article
  5. AKIR-1 regulates proteasome subcellular function in Caenorhabditis elegans. Pispa J, et al. iScience, 2023 Oct 20. PMID 37767001, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables small GTPase binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in macromolecule localization IEA
Inferred from Electronic Annotation
more info
  
involved_in nitrogen compound transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleocytoplasmic transport IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA export from nucleus IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA export from nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in tRNA re-export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tRNA re-export from nucleus IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
is_active_in nuclear matrix IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

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Preferred Names
Exportin-T
NP_001294153.1
  • Partially confirmed by transcript evidence
NP_001368437.1
  • Confirmed by transcript evidence
NP_501320.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    7916689..7924032 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068919.8 → NP_501320.2  Exportin-T [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501320.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GYQ7
    Conserved Domains (1) summary
    pfam08389
    Location:98 → 244
    Xpo1; Exportin 1-like protein

  2. NM_001307224.3 → NP_001294153.1  Exportin-T [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294153.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RQY2
    Conserved Domains (1) summary
    pfam08389
    Location:98 → 246
    Xpo1; Exportin 1-like protein

  3. NM_001380346.1 → NP_001368437.1  Exportin-T [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    W6RY26
Nucleotide Protein
Heading Accession and Version

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