sax-7 Fibronectin type-III domain-containing protein;Neuroglian [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sax-7
Official Full Name: Fibronectin type-III domain-containing protein;Neuroglian
Primary source: WormBase:WBGene00004732
Locus tag: CELE_C18F3.2
See related: AllianceGenome:WB:WBGene00004732
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables ankyrin binding activity. Involved in several processes, including gastrulation; neuron development; and regulation of cell morphogenesis. Located in several cellular components, including lateral plasma membrane; neuron projection membrane; and neuronal cell body membrane. Is expressed in several structures, including germ line; gonad; hypodermis; nervous system; and pharynx. Used to study MASA syndrome. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to several human genes including NFASC (neurofascin) and NRCAM (neuronal cell adhesion molecule). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sax-7 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 19

Sequence:: Chromosome: IV; NC_003282.8 (8062659..8084087)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuronal postdevelopmentally acting SAX-7S/L1CAM can function as cleaved fragments to maintain neuronal architecture in Caenorhabditis elegans.
Title: Neuronal postdevelopmentally acting SAX-7S/L1CAM can function as cleaved fragments to maintain neuronal architecture in Caenorhabditis elegans.
Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron.
Title: Harmonization of L1CAM expression facilitates axon outgrowth and guidance of a motor neuron.
dendrite development in C elegans requires the adhesion protein SAX-7/L1CAM and the cytoplasmic protein GRDN-1/CCDC88C to anchor dendrite endings at the nose
Title: Dendrites with specialized glial attachments develop by retrograde extension using SAX-7 and GRDN-1.
loss of the cell adhesion molecule (CAM) CDH-4/Fat-like cadherin causes dendrites to be ordered randomly, despite remaining bundled. Loss of the CAMs PTP-3/LAR or SAX-7/L1CAM causes dendrites to adopt an altered order, which becomes increasingly random as animals grow.
Title: Ordered arrangement of dendrites within a C. elegans sensory nerve bundle.
EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells
Title: Dynein and EFF-1 control dendrite morphology by regulating the localization pattern of SAX-7 in epidermal cells.
The ligand complex SAX-7/L1CAM and MNR-1 function at defined locations in the surrounding hypodermal tissue, whereas DMA-1 acts as the cognate receptor on the sensory neuron PVD. Mutations in this complex lead to dramatic defects in the formation, stabilization, and organization of the dendritic arbor.
Title: An extracellular adhesion molecule complex patterns dendritic branching and morphogenesis.
These findings suggest an unexpected interdependency of distinct Ig domain proteins, with one isoform of SAX-7, SAX-7L, inhibiting the function of the most adhesive isoform, SAX-7S, and this inhibition being relieved by ZIG-5 and ZIG-8.
Title: The secreted immunoglobulin domain proteins ZIG-5 and ZIG-8 cooperate with L1CAM/SAX-7 to maintain nervous system integrity.
sax-7 and hmr-1 function redundantly in blastomere compaction and non-muscle myosin accumulation during C. elegans gastrulation.
Title: SAX-7/L1CAM and HMR-1/cadherin function redundantly in blastomere compaction and non-muscle myosin accumulation during Caenorhabditis elegans gastrulation.
the 6 Ig/5 FnIII domain protein SAX-7 acts autonomously in the nervous system to maintain axon position in the ventral nerve cord of the nematode.
Title: Functional dissection of the C. elegans cell adhesion molecule SAX-7, a homologue of human L1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C18F3.2 (e-PCR)
- UniSTS:308603

C18F3.3 (e-PCR)
- UniSTS:317894

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ankyrin binding	IPI Inferred from Physical Interaction more info	PubMed
enables cell adhesion molecule binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in apical constriction involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
involved_in cell migration involved in gastrulation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell-cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dendrite self-avoidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in dendrite self-avoidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in embryo development ending in birth or egg hatching	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in establishment of mitotic spindle orientation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of dendrite morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite extension	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of dendrite extension	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of dendrite morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in system development	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in adherens junction	IDA Inferred from Direct Assay more info	PubMed
located_in axolemma	IDA Inferred from Direct Assay more info	PubMed
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite membrane	IDA Inferred from Direct Assay more info	PubMed
located_in lateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body membrane	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IDA Inferred from Direct Assay more info	PubMed
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in sarcomere	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Fibronectin type-III domain-containing protein;Neuroglian

NP_001033394.1

Partially confirmed by transcript evidence

NP_001033395.1

Confirmed by transcript evidence

NP_001033396.1

Confirmed by transcript evidence

NP_001033397.1

Confirmed by transcript evidence

NP_001294161.1

Confirmed by transcript evidence

NP_001294162.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8062659..8084087

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001038307.5 → NP_001033396.1 Neuroglian [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001033396.1

Status: REVIEWED

UniProtKB/TrEMBL

Q53U87

Conserved Domains (7) summary

smart00409
Location:453 → 534

IG; Immunoglobulin

cd00063
Location:755 → 857

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:64 → 128

Ig; Immunoglobulin domain

pfam00041
Location:866 → 977

fn3; Fibronectin type III domain

pfam13882
Location:1238 → 1310

Bravo_FIGEY; Bravo-like intracellular region

pfam13927
Location:258 → 327

Ig_3; Immunoglobulin domain

cl11960
Location:350 → 429

Ig; Immunoglobulin domain
NM_001038306.6 → NP_001033395.1 Neuroglian [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001033395.1

Status: REVIEWED

UniProtKB/TrEMBL

Q4PIU9

Conserved Domains (7) summary

smart00409
Location:453 → 534

IG; Immunoglobulin

cd00063
Location:755 → 857

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

cd00096
Location:64 → 128

Ig; Immunoglobulin domain

pfam00041
Location:866 → 977

fn3; Fibronectin type III domain

pfam13882
Location:1238 → 1307

Bravo_FIGEY; Bravo-like intracellular region

pfam13927
Location:258 → 327

Ig_3; Immunoglobulin domain

cl11960
Location:350 → 429

Ig; Immunoglobulin domain
NM_001038305.3 → NP_001033394.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001033394.1

Status: REVIEWED

UniProtKB/TrEMBL

Q18100

Conserved Domains (6) summary

smart00409
Location:269 → 350

IG; Immunoglobulin

cd00063
Location:571 → 673

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:682 → 793

fn3; Fibronectin type III domain

pfam13882
Location:1054 → 1123

Bravo_FIGEY; Bravo-like intracellular region

pfam13927
Location:74 → 143

Ig_3; Immunoglobulin domain

cl11960
Location:166 → 245

Ig; Immunoglobulin domain
NM_001038308.4 → NP_001033397.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001033397.1

Status: REVIEWED

UniProtKB/TrEMBL

Q53U86

Conserved Domains (6) summary

smart00410
Location:269 → 350

IG_like; Immunoglobulin like

cd00063
Location:571 → 673

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam00041
Location:682 → 793

fn3; Fibronectin type III domain

pfam13882
Location:1054 → 1126

Bravo_FIGEY; Bravo-like intracellular region

pfam13927
Location:74 → 143

Ig_3; Immunoglobulin domain

cl11960
Location:166 → 245

Ig; Immunoglobulin domain
NM_001307233.3 → NP_001294162.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294162.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RTH3

Conserved Domains (2) summary

cd00063
Location:25 → 102

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13882
Location:159 → 228

Bravo_FIGEY; Bravo-like intracellular region
NM_001307232.3 → NP_001294161.1 Fibronectin type-III domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001294161.1

Status: REVIEWED

UniProtKB/TrEMBL

W6RRX6

Conserved Domains (2) summary

cd00063
Location:25 → 102

FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

pfam13882
Location:159 → 231

Bravo_FIGEY; Bravo-like intracellular region