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sph-1 MARVEL domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177608, updated on 2-Nov-2024

Summary

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Official Symbol
sph-1
Official Full Name
MARVEL domain-containing protein
Primary source
WormBase:WBGene00004979
Locus tag
CELE_F42G8.11
See related
AllianceGenome:WB:WBGene00004979
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Located in cytoplasmic vesicle. Is expressed in anal sphincter muscle and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in non-syndromic X-linked intellectual disability 96. Orthologous to several human genes including SYPL1 (synaptophysin like 1) and SYNPR (synaptoporin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sph-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (8132175..8133558, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Rhodanese domain-containing protein Neighboring gene ncRNA Neighboring gene NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial Neighboring gene Molybdopterin-synthase sulfurtransferase Neighboring gene ncRNA Neighboring gene Cytochrome b-c1 complex subunit Rieske, mitochondrial Neighboring gene ncRNA Neighboring gene Interactor with SLO-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Synaptic tetraspan vesicle membrane proteins are conserved but not needed for synaptogenesis and neuronal function in Caenorhabditis elegans. Abraham C, et al. Proc Natl Acad Sci U S A, 2006 May 23. PMID 16698939, Free PMC Article
  2. Maintenance of the intestinal tube in Caenorhabditis elegans: the role of the intermediate filament protein IFC-2. Hüsken K, et al. Differentiation, 2008 Oct. PMID 18452552
  3. Inositol monophosphatase regulates localization of synaptic components and behavior in the mature nervous system of C. elegans. Tanizawa Y, et al. Genes Dev, 2006 Dec 1. PMID 17158747, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Component Evidence Code Pubs
located_in cytoplasmic vesicle IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in synaptic vesicle IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
MARVEL domain-containing protein
NP_501360.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8132175..8133558 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_068959.8 → NP_501360.2  MARVEL domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501360.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O44511
    Conserved Domains (1) summary
    pfam01284
    Location:85 → 210
    MARVEL; Membrane-associating domain
Nucleotide Protein
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