isp-1 Cytochrome b-c1 complex subunit Rieske, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: isp-1
Official Full Name: Cytochrome b-c1 complex subunit Rieske, mitochondrial
Primary source: WormBase:WBGene00002162
Locus tag: CELE_F42G8.12
See related: AllianceGenome:WB:WBGene00002162
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable oxidoreductase activity. Involved in several processes, including mitochondrial electron transport, ubiquinol to cytochrome c; regulation of gene expression; and regulation of protein phosphorylation. Predicted to be located in mitochondrial inner membrane. Predicted to be part of respiratory chain complex III. Is expressed in several structures, including enteric muscle; intestine; nervous system; rectal epithelium; and reproductive system. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to human UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1) and UQCRFS1P1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 pseudogene 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See isp-1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (8134016..8136055, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Gating and control processes influence the function of ISP-1 in mediating pleiotropic phenotypes including developmental rate, movement, sensitivity to stress, and longevity.
Title: Tether mutations that restore function and suppress pleiotropic phenotypes of the C. elegans isp-1(qm150) Rieske iron-sulfur protein.
stress response, and/or fecundity of isp-1(qm150) Mit mutants relative to wild-type animalsstress response, and/or fecundity of isp-1(qm150) Mit mutants relative to wild-type animals
Title: TAF-4 is required for the life extension of isp-1, clk-1 and tpk-1 Mit mutants.
ROS production by mitochondrial mutants and found that isp-1 and nuo-6 mutants have increased generation of the superoxide anion but not increased levels of other ROS and that this increase is necessary and sufficient for longevity.
Title: A mitochondrial superoxide signal triggers increased longevity in Caenorhabditis elegans.
found that the lifespan increase induced by nuo-6(RNAi) is fully additive to that induced by isp-1(qm150), and the increase induced by isp-1(RNAi) is fully additive to that induced by nuo-6(qm200)
Title: Two modes of mitochondrial dysfunction lead independently to lifespan extension in Caenorhabditis elegans.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F42G8.12 (e-PCR)
- UniSTS:310288

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables ubiquinol-cytochrome-c reductase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of gene expression	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of nematode larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrial inner membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex III	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Cytochrome b-c1 complex subunit Rieske, mitochondrial

NP_501361.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8134016..8136055 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068960.6 → NP_501361.1 Cytochrome b-c1 complex subunit Rieske, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501361.1

Status: REVIEWED

UniProtKB/TrEMBL

O44512

Conserved Domains (3) summary

cd03470
Location:152 → 274

Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...

TIGR01416
Location:109 → 274

Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit

pfam02921
Location:80 → 146

UCR_TM; Ubiquinol cytochrome reductase transmembrane region