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nhr-66 Nuclear hormone receptor family member nhr-66 [ Caenorhabditis elegans ]

Gene ID: 177618, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-66
Official Full Name
Nuclear hormone receptor family member nhr-66
Primary source
WormBase:WBGene00003656
Locus tag
CELE_T09A12.4
See related
AllianceGenome:WB:WBGene00003656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including head ganglion; hypodermis; neurons; terminal bulb; and ventral nerve cord. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-66 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (8226331..8236602, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ion transport domain-containing protein Neighboring gene Glutathione peroxidase Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AraC family transcriptional regulator Neighboring gene WAPL domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Transcriptional suppression of sphingolipid catabolism controls pathogen resistance in C. elegans. Nasrallah MA, et al. PLoS Pathog, 2023 Oct. PMID 37906605, Free PMC Article
  2. Gain-of-Function Alleles in Caenorhabditis elegans Nuclear Hormone Receptor nhr-49 Are Functionally Distinct. Lee K, et al. PLoS One, 2016. PMID 27618178, Free PMC Article
  3. Dual Role of an mps-2/KCNE-Dependent Pathway in Long-Term Memory and Age-Dependent Memory Decline. Fenyves BG, et al. Curr Biol, 2021 Feb 8. PMID 33259792
  4. A gene-centered C. elegans protein-DNA interaction network provides a framework for functional predictions. Fuxman Bass JI, et al. Mol Syst Biol, 2016 Oct 24. PMID 27777270, Free PMC Article
  5. Nuclear receptors NHR-49 and NHR-79 promote peroxisome proliferation to compensate for aldehyde dehydrogenase deficiency in C. elegans. Zeng L, et al. PLoS Genet, 2021 Jul. PMID 34237064, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-66
NP_001023369.1
  • Confirmed by transcript evidence
NP_001294133.1
  • Confirmed by transcript evidence
NP_001294134.1
  • Confirmed by transcript evidence
NP_001294135.1
  • Confirmed by transcript evidence
NP_001294136.1
  • Confirmed by transcript evidence
NP_001368431.1
  • Confirmed by transcript evidence
NP_001370926.1
  • Confirmed by transcript evidence
NP_001379637.1
  • Confirmed by transcript evidence
NP_741462.1
  • Confirmed by transcript evidence
NP_741463.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8226331..8236602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171396.7 → NP_741462.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741462.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KYJ7, H2KYJ8, Q5W611, Q8MXH0, W6RQQ7, W6RRP4, W6RT69, W6RT76, W6RXQ9, W6SB62
    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:269 → 346
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:474 → 654
    HOLI; Ligand binding domain of hormone receptors

  2. NM_171397.8 → NP_741463.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741463.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:113 → 190
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:318 → 498
    HOLI; Ligand binding domain of hormone receptors

  3. NM_001392346.1 → NP_001379637.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:62 → 139
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    pfam00104
    Location:263 → 463
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor

  4. NM_001307205.2 → NP_001294134.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294134.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:267 → 344
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:472 → 652
    HOLI; Ligand binding domain of hormone receptors

  5. NM_001383139.1 → NP_001370926.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:64 → 141
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    pfam00104
    Location:265 → 465
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor

  6. NM_001307206.3 → NP_001294135.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:193 → 270
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:398 → 578
    HOLI; Ligand binding domain of hormone receptors

  7. NM_001028198.5 → NP_001023369.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:195 → 272
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:400 → 580
    HOLI; Ligand binding domain of hormone receptors

  8. NM_001307207.3 → NP_001294136.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294136.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:115 → 192
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:320 → 500
    HOLI; Ligand binding domain of hormone receptors

  9. NM_001380356.1 → NP_001368431.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:53 → 130
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    pfam00104
    Location:254 → 454
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor

  10. NM_001307204.3 → NP_001294133.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:55 → 132
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:260 → 440
    HOLI; Ligand binding domain of hormone receptors
Nucleotide Protein
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