U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

nhr-66 Nuclear hormone receptor family member nhr-66 [ Caenorhabditis elegans ]

Gene ID: 177618, updated on 2-Nov-2024

Summary

Official Symbol
nhr-66
Official Full Name
Nuclear hormone receptor family member nhr-66
Primary source
WormBase:WBGene00003656
Locus tag
CELE_T09A12.4
See related
AllianceGenome:WB:WBGene00003656
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in several structures, including head ganglion; hypodermis; neurons; terminal bulb; and ventral nerve cord. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See nhr-66 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
12
Sequence:
Chromosome: IV; NC_003282.8 (8226331..8236602, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Ion transport domain-containing protein Neighboring gene Glutathione peroxidase Neighboring gene Stress-associated endoplasmic reticulum protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene AraC family transcriptional regulator Neighboring gene WAPL domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Nuclear hormone receptor family member nhr-66
NP_001023369.1
  • Confirmed by transcript evidence
NP_001294133.1
  • Confirmed by transcript evidence
NP_001294134.1
  • Confirmed by transcript evidence
NP_001294135.1
  • Confirmed by transcript evidence
NP_001294136.1
  • Confirmed by transcript evidence
NP_001368431.1
  • Confirmed by transcript evidence
NP_001370926.1
  • Confirmed by transcript evidence
NP_001379637.1
  • Confirmed by transcript evidence
NP_741462.1
  • Confirmed by transcript evidence
NP_741463.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8226331..8236602 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171396.7NP_741462.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741462.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2KYJ7, H2KYJ8, Q5W611, Q8MXH0, W6RQQ7, W6RRP4, W6RT69, W6RT76, W6RXQ9, W6SB62
    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:269346
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:474654
    HOLI; Ligand binding domain of hormone receptors
  2. NM_171397.8NP_741463.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741463.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:113190
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:318498
    HOLI; Ligand binding domain of hormone receptors
  3. NM_001392346.1NP_001379637.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:62139
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    pfam00104
    Location:263463
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor
  4. NM_001307205.2NP_001294134.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294134.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:267344
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:472652
    HOLI; Ligand binding domain of hormone receptors
  5. NM_001383139.1NP_001370926.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:64141
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    pfam00104
    Location:265465
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor
  6. NM_001307206.3NP_001294135.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294135.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:193270
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:398578
    HOLI; Ligand binding domain of hormone receptors
  7. NM_001028198.5NP_001023369.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023369.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTD9
    Conserved Domains (2) summary
    cd06960
    Location:195272
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:400580
    HOLI; Ligand binding domain of hormone receptors
  8. NM_001307207.3NP_001294136.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294136.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:115192
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:320500
    HOLI; Ligand binding domain of hormone receptors
  9. NM_001380356.1NP_001368431.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:53130
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    pfam00104
    Location:254454
    Hormone_recep; Ligand-binding domain of nuclear hormone receptor
  10. NM_001307204.3NP_001294133.1  Nuclear hormone receptor family member nhr-66 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294133.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9GTE0
    Conserved Domains (2) summary
    cd06960
    Location:55132
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
    smart00430
    Location:260440
    HOLI; Ligand binding domain of hormone receptors