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vit-6 Vitellogenin-6 [ Caenorhabditis elegans ]

Gene ID: 177619, updated on 2-Nov-2024

Summary

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Official Symbol
vit-6
Official Full Name
Vitellogenin-6
Primary source
WormBase:WBGene00006930
Locus tag
CELE_K07H8.6
See related
AllianceGenome:WB:WBGene00006930
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable lipid transporter activity. Involved in negative regulation of protein oxidation; negative regulation of reactive oxygen species biosynthetic process; and positive regulation of cholesterol import. Predicted to be located in extracellular region. Is expressed in intestine. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vit-6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (8261157..8266459)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Lipoprotein Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene F-box associated domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Two distinct yolk lipoprotein complexes from Caenorhabditis elegans. Sharrock WJ, et al. J Biol Chem, 1990 Aug 25. PMID 2387862
  2. Phytoestrogens genistein and daidzein affect immunity in the nematode Caenorhabditis elegans via alterations of vitellogenin expression. Fischer M, et al. Mol Nutr Food Res, 2012 Jun. PMID 22707270
  3. SL1 trans-splicing specified by AU-rich synthetic RNA inserted at the 5' end of Caenorhabditis elegans pre-mRNA. Conrad R, et al. RNA, 1995 Apr. PMID 7585246, Free PMC Article
  4. Dynamic changes of the Caenorhabditis elegans proteome during ontogenesis assessed by quantitative analysis with 15N metabolic labeling. Geillinger KE, et al. J Proteome Res, 2012 Sep 7. PMID 22900790
  5. Regulated expression of a vitellogenin fusion gene in transgenic nematodes. Spieth J, et al. Dev Biol, 1988 Nov. PMID 3181632

See all (77) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that induction of vit-6 (in response to the phytoestrogen daidzein) increases resistance of C. elegans to pathogenic bacteria (Photorhabdus luminescens here) and heat shock/stress.
    Title: Phytoestrogens genistein and daidzein affect immunity in the nematode Caenorhabditis elegans via alterations of vitellogenin expression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid transporter activity IEA
Inferred from Electronic Annotation
more info
  
enables nutrient reservoir activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of protein oxidation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of reactive oxygen species biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cholesterol import IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Vitellogenin-6
NP_001023274.1
  • Confirmed by transcript evidence
NP_001023276.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8261157..8266459
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028103.4 → NP_001023274.1  Vitellogenin-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023274.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P18948
    Conserved Domains (3) summary
    smart00216
    Location:1339 → 1495
    VWD; von Willebrand factor (vWF) type D domain
    pfam01347
    Location:34 → 646
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam09172
    Location:679 → 979
    DUF1943; Domain of unknown function (DUF1943)

  2. NM_001028105.7 → NP_001023276.1  Vitellogenin-6 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023276.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45176, P18948, Q7KPP7, Q7YXH2
    Conserved Domains (3) summary
    smart00216
    Location:1339 → 1495
    VWD; von Willebrand factor (vWF) type D domain
    pfam01347
    Location:34 → 646
    Vitellogenin_N; Lipoprotein amino terminal region
    pfam09172
    Location:679 → 979
    DUF1943; Domain of unknown function (DUF1943)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P18948.5

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