daf-31 N-alpha-acetyltransferase daf-31 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: daf-31
Official Full Name: N-alpha-acetyltransferase daf-31
Primary source: WormBase:WBGene00000923
Locus tag: CELE_K07H8.3
See related: AllianceGenome:WB:WBGene00000923
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable peptide-glutamate-alpha-N-acetyltransferase activity and peptide-serine-alpha-N-acetyltransferase activity. Involved in dauer exit and determination of adult lifespan. Predicted to be part of NatA complex. Is expressed in hypodermis; intestine; nervous system; and pharynx. Human ortholog(s) of this gene implicated in Ogden syndrome and syndromic microphthalmia 1. Orthologous to human NAA10 (N-alpha-acetyltransferase 10, NatA catalytic subunit) and NAA11 (N-alpha-acetyltransferase 11, NatA catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See daf-31 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 3

Sequence:: Chromosome: IV; NC_003282.8 (8290273..8291496)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan.
Title: daf-31 encodes the catalytic subunit of N alpha-acetyltransferase that regulates Caenorhabditis elegans development, metabolism and adult lifespan.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

K07H8.3 (e-PCR)
- UniSTS:316022

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables acyltransferase activity, transferring groups other than amino-acyl groups	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	IEA Inferred from Electronic Annotation more info
enables peptide alpha-N-acetyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables peptide-glutamate-alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables peptide-serine-alpha-N-acetyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in N-terminal protein amino acid acetylation	IEA Inferred from Electronic Annotation more info
involved_in dauer exit	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in determination of adult lifespan	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organismal reproductive process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in multicellular organismal reproductive process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nematode larval development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of NatA complex	IBA Inferred from Biological aspect of Ancestor more info
part_of NatA complex	IEA Inferred from Electronic Annotation more info
part_of NatA complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: N-alpha-acetyltransferase daf-31

NP_501392.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8290273..8291496

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_068991.7 → NP_501392.1 N-alpha-acetyltransferase daf-31 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_501392.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O61219

Conserved Domains (2) summary

COG0456
Location:1 → 153

RimI; Ribosomal protein S18 acetylase RimI and related acetyltransferases [Translation, ribosomal structure and biogenesis]

pfam00583
Location:47 → 123

Acetyltransf_1; Acetyltransferase (GNAT) family