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spp-10 Saposin B-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177651, updated on 2-Nov-2024

Summary

Official Symbol
spp-10
Official Full Name
Saposin B-type domain-containing protein
Primary source
WormBase:WBGene00004995
Locus tag
CELE_C28C12.7
See related
AllianceGenome:WB:WBGene00004995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in sphingolipid metabolic process. Predicted to be located in lysosome. Is expressed in body wall musculature; intestine; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; lung disease (multiple); respiratory syncytial virus infectious disease; sphingolipidosis (multiple); and toxic shock syndrome. Orthologous to several human genes including PSAP (prosaposin) and PSAPL1 (prosaposin like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See spp-10 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (8477180..8480656)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Helix-loop-helix protein hlh-12 Neighboring gene Saposin B-type domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Saposin B-type domain-containing protein
NP_741465.1
  • Confirmed by transcript evidence
NP_741466.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8477180..8480656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171399.7NP_741465.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741465.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18276, Q18278
    Conserved Domains (2) summary
    smart00741
    Location:137213
    SapB; Saposin (B) Domains
    pfam03489
    Location:181213
    SapB_2; Saposin-like type B, region 2
  2. NM_171400.6NP_741466.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741466.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4JFH6
    Conserved Domains (3) summary
    smart00741
    Location:137213
    SapB; Saposin (B) Domains
    pfam03489
    Location:181213
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:139174
    SapB_1; Saposin-like type B, region 1