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spp-10 Saposin B-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177651, updated on 2-Nov-2024

Summary

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Official Symbol
spp-10
Official Full Name
Saposin B-type domain-containing protein
Primary source
WormBase:WBGene00004995
Locus tag
CELE_C28C12.7
See related
AllianceGenome:WB:WBGene00004995
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in sphingolipid metabolic process. Predicted to be located in lysosome. Is expressed in body wall musculature; intestine; nervous system; non-striated muscle; and reproductive system. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; lung disease (multiple); respiratory syncytial virus infectious disease; sphingolipidosis (multiple); and toxic shock syndrome. Orthologous to several human genes including PSAP (prosaposin) and PSAPL1 (prosaposin like 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See spp-10 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (8477180..8480656)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene Transmembrane protein Neighboring gene Helix-loop-helix protein hlh-12 Neighboring gene Saposin B-type domain-containing protein Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. High-Throughput All-Optical Analysis of Synaptic Transmission and Synaptic Vesicle Recycling in Caenorhabditis elegans. Wabnig S, et al. PLoS One, 2015. PMID 26312752, Free PMC Article
  2. Degradation of hexosylceramides is required for timely corpse clearance via formation of cargo-containing phagolysosomal vesicles. Holzapfel R, et al. Eur J Cell Biol, 2024 Jun. PMID 38582051
  3. Synthetic lethal analysis of Caenorhabditis elegans posterior embryonic patterning genes identifies conserved genetic interactions. Baugh LR, et al. Genome Biol, 2005. PMID 15892873, Free PMC Article
  4. In-vivo screening implicates endoribonuclease Regnase-1 in modulating senescence-associated lysosomal changes. Venz R, et al. Geroscience, 2024 Apr. PMID 37644339, Free PMC Article
  5. The homeodomain protein PAL-1 specifies a lineage-specific regulatory network in the C. elegans embryo. Baugh LR, et al. Development, 2005 Apr. PMID 15772128

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in lysosome IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Saposin B-type domain-containing protein
NP_741465.1
  • Confirmed by transcript evidence
NP_741466.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8477180..8480656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_171399.7 → NP_741465.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741465.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18276, Q18278
    Conserved Domains (2) summary
    smart00741
    Location:137 → 213
    SapB; Saposin (B) Domains
    pfam03489
    Location:181 → 213
    SapB_2; Saposin-like type B, region 2

  2. NM_171400.6 → NP_741466.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_741466.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q4JFH6
    Conserved Domains (3) summary
    smart00741
    Location:137 → 213
    SapB; Saposin (B) Domains
    pfam03489
    Location:181 → 213
    SapB_2; Saposin-like type B, region 2
    pfam05184
    Location:139 → 174
    SapB_1; Saposin-like type B, region 1
Nucleotide Protein
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