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spp-8 Saposin B-type domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177652, updated on 17-Oct-2024

Summary

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Official Symbol
spp-8
Official Full Name
Saposin B-type domain-containing protein
Primary source
WormBase:WBGene00004993
Locus tag
CELE_C28C12.5
See related
AllianceGenome:WB:WBGene00004993
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be active in extracellular space. Is expressed in intestine. Human ortholog(s) of this gene implicated in late onset Parkinson's disease; lung disease (multiple); respiratory syncytial virus infectious disease; sphingolipidosis (multiple); and toxic shock syndrome. Orthologous to several human genes including PSAP (prosaposin). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See spp-8 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (8481664..8483621)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Transmembrane protein Neighboring gene Saposin B-type domain-containing protein Neighboring gene Helix-loop-helix protein hlh-12 Neighboring gene SXP/RAL-2 family protein Ani s 5-like cation-binding domain-containing protein Neighboring gene SXP /RAL-2-Like protein Family

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. NFYB-1 regulates mitochondrial function and longevity via lysosomal prosaposin. Tharyan RG, et al. Nat Metab, 2020 May. PMID 32694663
  2. Responses to infection and possible recognition strategies in the innate immune system of Caenorhabditis elegans. Nicholas HR, et al. Mol Immunol, 2004 Jul. PMID 15183927
  3. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

General protein information

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Preferred Names
Saposin B-type domain-containing protein
NP_501447.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8481664..8483621
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069046.7 → NP_501447.1  Saposin B-type domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501447.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18279
    Conserved Domains (1) summary
    smart00741
    Location:238 → 312
    SapB; Saposin (B) Domains
Nucleotide Protein
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Gene LinkOut

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