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cks-1 Cyclin-dependent kinases regulatory subunit [ Caenorhabditis elegans ]

Gene ID: 177658, updated on 2-Nov-2024

Summary

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Official Symbol
cks-1
Official Full Name
Cyclin-dependent kinases regulatory subunit
Primary source
WormBase:WBGene00001051
Locus tag
CELE_C09G4.3
See related
AllianceGenome:WB:WBGene00001051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein kinase binding activity. Involved in regulation of mitotic cell cycle, embryonic. Predicted to be located in nucleus. Predicted to be part of SCF ubiquitin ligase complex and cyclin-dependent protein kinase holoenzyme complex. Orthologous to several human genes including CKS1B (CDC28 protein kinase regulatory subunit 1B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cks-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
2
Sequence:
Chromosome: IV; NC_003282.8 (8513919..8514725)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene FYVE, RhoGEF and PH domain-containing protein tag-77 Neighboring gene Polycomb protein mes-6 Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein;cGMP-dependent protein kinase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Depletion of a Cks homolog in C. elegans embryos uncovers a post-metaphase role in both meiosis and mitosis. Polinko ES, et al. Curr Biol, 2000 Nov 16. PMID 11102813
  2. SL1 trans splicing and 3'-end formation in a novel class of Caenorhabditis elegans operon. Williams C, et al. Mol Cell Biol, 1999 Jan. PMID 9858561, Free PMC Article
  3. Cortical granule exocytosis in C. elegans is regulated by cell cycle components including separase. Bembenek JN, et al. Development, 2007 Nov. PMID 17913784, Free PMC Article
  4. The Conserved Kinases CDK-1, GSK-3, KIN-19, and MBK-2 Promote OMA-1 Destruction to Regulate the Oocyte-to-Embryo Transition in C. elegans. Shirayama M, et al. Curr Biol, 2006 Jan 10. PMID 16343905
  5. Host CDK-1 and formin mediate microvillar effacement induced by enterohemorrhagic Escherichia coli. Huang CR, et al. Nat Commun, 2021 Jan 4. PMID 33397943, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of SCF ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IC
Inferred by Curator
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Cyclin-dependent kinases regulatory subunit
NP_001379647.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8513919..8514725
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392353.1 → NP_001379647.1  Cyclin-dependent kinases regulatory subunit [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17868
    Conserved Domains (1) summary
    pfam01111
    Location:10 → 75
    CKS; Cyclin-dependent kinase regulatory subunit
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17868.1

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