pkg-2 Protein kinase domain-containing protein;cGMP-dependent protein kinase [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pkg-2
Official Full Name: Protein kinase domain-containing protein;cGMP-dependent protein kinase
Primary source: WormBase:WBGene00015650
Locus tag: CELE_C09G4.2
See related: AllianceGenome:WB:WBGene00015650
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable ATP binding activity; cGMP binding activity; and cGMP-dependent protein kinase activity. Predicted to be involved in receptor guanylyl cyclase signaling pathway. Human ortholog(s) of this gene implicated in thoracic aortic aneurysm. Orthologous to human PRKG1 (protein kinase cGMP-dependent 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pkg-2 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 12

Sequence:: Chromosome: IV; NC_003282.8 (8520894..8538187)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C09G4.2 (e-PCR)
- UniSTS:309025

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cGMP binding	IEA Inferred from Electronic Annotation more info
enables cGMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables cyclic nucleotide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in receptor guanylyl cyclase signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Protein kinase domain-containing protein;cGMP-dependent protein kinase

NP_741467.1

Confirmed by transcript evidence

NP_741468.1

Confirmed by transcript evidence

NP_741469.2

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

8520894..8538187

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_171401.10 → NP_741467.1 cGMP-dependent protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741467.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KYN2

Conserved Domains (4) summary

PTZ00263
Location:295 → 599

PTZ00263; protein kinase A catalytic subunit; Provisional

COG0664
Location:66 → 173

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:72 → 173

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:316 → 572

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_171402.6 → NP_741468.1 cGMP-dependent protein kinase [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741468.1

Status: REVIEWED

UniProtKB/TrEMBL

H2KYN1

Conserved Domains (4) summary

PTZ00263
Location:259 → 563

PTZ00263; protein kinase A catalytic subunit; Provisional

COG0664
Location:30 → 137

Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]

cd00038
Location:36 → 137

CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...

cd05572
Location:280 → 536

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)
NM_171403.6 → NP_741469.2 Protein kinase domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741469.2

Status: REVIEWED

UniProtKB/TrEMBL

Q8MQE2

Conserved Domains (2) summary

smart00133
Location:293 → 344

S_TK_X; Extension to Ser/Thr-type protein kinases

cd05572
Location:43 → 299

STKc_cGK; Catalytic domain of the Serine/Threonine Kinase, cGMP-dependent protein kinase (cGK or PKG)