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hst-1 Heparan sulfate N-sulfotransferase 1 [ Caenorhabditis elegans ]

Gene ID: 177675, updated on 2-Nov-2024

Summary

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Official Symbol
hst-1
Official Full Name
Heparan sulfate N-sulfotransferase 1
Primary source
WormBase:WBGene00002028
Locus tag
CELE_F08B4.6
See related
AllianceGenome:WB:WBGene00002028
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable [heparan sulfate]-glucosamine N-sulfotransferase activity and deacetylase activity. Predicted to be involved in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be active in Golgi apparatus. Human ortholog(s) of this gene implicated in autosomal recessive intellectual developmental disorder 46. Orthologous to several human genes including NDST1 (N-deacetylase and N-sulfotransferase 1); NDST2 (N-deacetylase and N-sulfotransferase 2); and NDST3 (N-deacetylase and N-sulfotransferase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hst-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (8688276..8691513, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative DNA polymerase epsilon subunit 2 Neighboring gene U1 small nuclear ribonucleoprotein C Neighboring gene VWFA domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heparan sulphate sulphotransferase expression in mice and Caenorhabditis elegans. Turnbull J, et al. Biochem Soc Trans, 2003 Apr. PMID 12653634
  2. Syndecan defines precise spindle orientation by modulating Wnt signaling in C. elegans. Dejima K, et al. Development, 2014 Nov. PMID 25344071, Free PMC Article
  3. Combinatorial roles of heparan sulfate proteoglycans and heparan sulfates in Caenorhabditis elegans neural development. Kinnunen TK. PLoS One, 2014. PMID 25054285, Free PMC Article
  4. The nematode Caenorhabditis elegans as a model to study the roles of proteoglycans. Berninsone PM, et al. Glycoconj J, 2002 May-Jun. PMID 12975612
  5. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables [heparan sulfate]-glucosamine N-sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables sulfotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Heparan sulfate N-sulfotransferase 1
NP_501491.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8688276..8691513 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069090.6 → NP_501491.4  Heparan sulfate N-sulfotransferase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501491.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19197, Q966W3, Q966W4, Q966W5, Q966W6
    Conserved Domains (2) summary
    pfam12062
    Location:18 → 491
    HSNSD; heparan sulfate-N-deacetylase
    cl21551
    Location:582 → 822
    Sulfotransfer_1; Sulfotransferase domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q966W3.1

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