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otub-3 OTU domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177679, updated on 2-Nov-2024

Summary

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Official Symbol
otub-3
Official Full Name
OTU domain-containing protein
Primary source
WormBase:WBGene00009007
Locus tag
CELE_F21D5.2
See related
AllianceGenome:WB:WBGene00009007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cysteine-type deubiquitinase activity. Is expressed in nervous system. Orthologous to human OTUD6A (OTU deubiquitinase 6A) and OTUD6B (OTU deubiquitinase 6B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See otub-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (8728177..8730510)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene C2H2-type domain-containing protein Neighboring gene Phosphoacetylglucosamine mutase Neighboring gene ncRNA Neighboring gene Multicopper oxidase;Plastocyanin-like domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene HTH CENPB-type domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rewiring of the ubiquitinated proteome determines ageing in C. elegans. Koyuncu S, et al. Nature, 2021 Aug. PMID 34321666, Free PMC Article
  2. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
OTU domain-containing protein
NP_001255318.1
  • Confirmed by transcript evidence
NP_001255319.1
  • Partially confirmed by transcript evidence
NP_001255320.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8728177..8730510
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268389.4 → NP_001255318.1  OTU domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255318.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19681
    Conserved Domains (2) summary
    COG5539
    Location:3 → 305
    COG5539; Predicted cysteine protease (OTU family) [Posttranslational modification, protein turnover, chaperones]
    pfam02338
    Location:173 → 303
    OTU; OTU-like cysteine protease

  2. NM_001268390.4 → NP_001255319.1  OTU domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255319.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GU86
    Conserved Domains (1) summary
    pfam02338
    Location:194 → 324
    OTU; OTU-like cysteine protease

  3. NM_001268391.3 → NP_001255320.1  OTU domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255320.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GU87
    Conserved Domains (1) summary
    pfam02338
    Location:132 → 262
    OTU; OTU-like cysteine protease
Nucleotide Protein
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