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parg-1 Poly(ADP-ribose) glycohydrolase 1;poly(ADP-ribose) glycohydrolase [ Caenorhabditis elegans ]

Gene ID: 177683, updated on 2-Nov-2024

Summary

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Official Symbol
parg-1
Official Full Name
Poly(ADP-ribose) glycohydrolase 1;poly(ADP-ribose) glycohydrolase
Primary source
WormBase:WBGene00004051
Locus tag
CELE_F20C5.1
See related
AllianceGenome:WB:WBGene00004051
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables poly(ADP-ribose) glycohydrolase activity. Involved in nucleotide-sugar metabolic process and response to gamma radiation. Located in neuron projection and nucleus. Is expressed in anal depressor muscle; body wall musculature; intestine; nervous system; and pharynx. Orthologous to human BPHL (biphenyl hydrolase like) and PARG (poly(ADP-ribose) glycohydrolase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See parg-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (8746252..8752676)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Signal recognition particle 54 kDa protein Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene Enlarged germline granules protein 1 Neighboring gene Uncharacterized protein Neighboring gene Kinesin-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans. Nicolai MM, et al. Int J Mol Sci, 2021 Oct 9. PMID 34681565, Free PMC Article
  2. Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity. Janisiw E, et al. Nat Commun, 2020 Sep 25. PMID 32978394, Free PMC Article
  3. Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression. St-Laurent JF, et al. DNA Repair (Amst), 2007 Mar 1. PMID 17188026
  4. Poly(ADP-ribose) metabolism analysis in the nematode Caenorhabditis elegans. St-Laurent JF, et al. Methods Mol Biol, 2011. PMID 21870275
  5. The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. Gagnon SN, et al. Biochem J, 2002 Nov 15. PMID 12145714, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
    Title: PARG and BRCA1-BARD1 cooperative function regulates DNA repair pathway choice during gametogenesis.
  2. Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans.
    Title: Effects of Manganese on Genomic Integrity in the Multicellular Model Organism Caenorhabditis elegans.
  3. Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity.
    Title: Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity.
  4. cloning of poly(ADP-ribose) glycohydrolases (pme-3).
    Title: Altered DNA damage response in Caenorhabditis elegans with impaired poly(ADP-ribose) glycohydrolases genes expression.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(ADP-ribose) glycohydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables poly(ADP-ribose) glycohydrolase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables poly(ADP-ribose) glycohydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables poly(ADP-ribose) glycohydrolase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in ATP generation from poly-ADP-D-ribose IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in DNA damage response IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in carbohydrate metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in nucleotide-sugar metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nucleotide-sugar metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in nucleotide-sugar metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA repair IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of DNA repair IEA
Inferred from Electronic Annotation
more info
  
involved_in response to gamma radiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Poly(ADP-ribose) glycohydrolase 1;poly(ADP-ribose) glycohydrolase
NP_001023135.1
  • Confirmed by transcript evidence
NP_001023136.1
  • Confirmed by transcript evidence
NP_001122772.1
  • Confirmed by transcript evidence
NP_001255324.1
  • Confirmed by transcript evidence
NP_001263754.1
  • Confirmed by transcript evidence
NP_001294060.1
  • Confirmed by transcript evidence
NP_001294061.1
  • Confirmed by transcript evidence
NP_001294062.1
  • Confirmed by transcript evidence
NP_001367109.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8746252..8752676
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001307133.3 → NP_001294062.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294062.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5LVA3
    Conserved Domains (1) summary
    pfam05028
    Location:401 → 718
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  2. NM_001276825.3 → NP_001263754.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263754.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L8EC33
    Conserved Domains (1) summary
    pfam05028
    Location:399 → 718
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  3. NM_001027965.4 → NP_001023136.1  Poly(ADP-ribose) glycohydrolase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023136.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q867X0
    Conserved Domains (1) summary
    pfam05028
    Location:381 → 700
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  4. NM_001307132.3 → NP_001294061.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294061.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M907
    Conserved Domains (2) summary
    COG5271
    Location:84 → 278
    MDN1; Midasin, AAA ATPase with vWA domain, involved in ribosome maturation [Translation, ribosomal structure and biogenesis]
    pfam05028
    Location:396 → 713
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  5. NM_001027964.5 → NP_001023135.1  Poly(ADP-ribose) glycohydrolase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023135.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19637, Q867X0
    Conserved Domains (1) summary
    pfam05028
    Location:398 → 717
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  6. NM_001307131.4 → NP_001294060.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294060.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    X5M5W8
    Conserved Domains (1) summary
    pfam05028
    Location:378 → 695
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  7. NM_001129300.4 → NP_001122772.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122772.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A5JYS4
    Conserved Domains (1) summary
    pfam05028
    Location:398 → 694
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)

  8. NM_001380380.2 → NP_001367109.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q5WRP7

  9. NM_001268395.3 → NP_001255324.1  poly(ADP-ribose) glycohydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255324.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GU97
    Conserved Domains (1) summary
    pfam05028
    Location:221 → 540
    PARG_cat; Poly (ADP-ribose) glycohydrolase (PARG)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q867X0.1

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