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spr-2 Suppressor of presenilin-2 [ Caenorhabditis elegans ]

Gene ID: 177704, updated on 2-Nov-2024

Summary

Official Symbol
spr-2
Official Full Name
Suppressor of presenilin-2
Primary source
WormBase:WBGene00005007
Locus tag
CELE_C27B7.1
See related
AllianceGenome:WB:WBGene00005007
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chromatin binding activity and histone binding activity. Involved in regulation of egg-laying behavior. Located in nucleus. Is expressed widely. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; gonadal dysgenesis; prostate cancer; and sudden infant death syndrome. Orthologous to several human genes including SETSIP (SET like protein) and SET (SET nuclear proto-oncogene). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See spr-2 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (8891462..8892747)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ABC2_membrane domain-containing protein;MARVEL domain-containing protein Neighboring gene CCCH-type zinc finger protein oma-1 Neighboring gene Phospholipid scramblase Neighboring gene Helicase ARIP4;Helicase ATP-binding domain-containing protein

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chromatin binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables histone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in nucleosome assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Suppressor of presenilin-2
NP_001021332.1
  • Confirmed by transcript evidence
NP_001021333.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    8891462..8892747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001026162.7NP_001021333.1  Suppressor of presenilin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021333.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JMA9
    Conserved Domains (1) summary
    pfam00956
    Location:34162
    NAP; Nucleosome assembly protein (NAP)
  2. NM_001026161.3NP_001021332.1  Suppressor of presenilin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001021332.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18240, Q9GPJ0
    Conserved Domains (1) summary
    pfam00956
    Location:34162
    NAP; Nucleosome assembly protein (NAP)