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wnk-1 Serine/threonine-protein kinase WNK [ Caenorhabditis elegans ]

Gene ID: 177743, updated on 2-Nov-2024

Summary

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Official Symbol
wnk-1
Official Full Name
Serine/threonine-protein kinase WNK
Primary source
WormBase:WBGene00006941
Locus tag
CELE_C46C2.1
See related
AllianceGenome:WB:WBGene00006941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables molecular condensate scaffold activity. Involved in several processes, including cell volume homeostasis; cellular hyperosmotic response; and multicellular organismal-level water homeostasis. Predicted to be active in cytoplasm. Is expressed in body wall musculature; excretory cell; hypodermis; and spermatheca. Used to study pseudohypoaldosteronism. Human ortholog(s) of this gene implicated in Prieto syndrome; hereditary sensory and autonomic neuropathy type 2A; hereditary sensory neuropathy; hypertension; and pseudohypoaldosteronism. Orthologous to several human genes including WNK1 (WNK lysine deficient protein kinase 1); WNK2 (WNK lysine deficient protein kinase 2); and WNK3 (WNK lysine deficient protein kinase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See wnk-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
15
Sequence:
Chromosome: IV; NC_003282.8 (9200103..9212242)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene C-type lectin domain-containing protein;SRCR domain-containing protein;Uncharacterized protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. WNK Kinases in Development and Disease. Rodan AR, et al. Curr Top Dev Biol, 2017. PMID 28236964, Free PMC Article
  2. Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans. Choe KP, et al. Am J Physiol Cell Physiol, 2007 Sep. PMID 17596296
  3. Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity. Hisamoto N, et al. EMBO Rep, 2008 Jan. PMID 18049475, Free PMC Article
  4. C. elegans STK39/SPAK ortholog-mediated inhibition of ClC anion channel activity is regulated by WNK-independent ERK kinase signaling. Falin RA, et al. Am J Physiol Cell Physiol, 2011 Mar. PMID 21160027, Free PMC Article
  5. Phosphoregulation of the Na-K-2Cl and K-Cl cotransporters by the WNK kinases. Kahle KT, et al. Biochim Biophys Acta, 2010 Dec. PMID 20637866, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results indicate that WNK-1 controls the tubular formation of excretory canals by activating GCK-3, resulting in downregulation of CIC channel activity.
    Title: Caenorhabditis elegans WNK-STE20 pathway regulates tube formation by modulating ClC channel activity.
  2. WNK-1 functions upstream of GCK-3 in a manner similar to that postulated for its mammalian homologs
    Title: Evolutionarily conserved WNK and Ste20 kinases are essential for acute volume recovery and survival after hypertonic shrinkage in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular condensate scaffold activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables potassium channel inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell volume homeostasis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cellular hyperosmotic response IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in hyperosmotic response IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in hyperosmotic response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in monoatomic ion homeostasis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multicellular organismal-level water homeostasis IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in multicellular organismal-level water homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in non-membrane-bounded organelle assembly IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of potassium ion import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase WNK
NP_001255368.1
  • Partially confirmed by transcript evidence
NP_001255369.1
  • Partially confirmed by transcript evidence
NP_001255370.1
  • Confirmed by transcript evidence
NP_001255371.1
  • Confirmed by transcript evidence
NP_001255372.1
  • Partially confirmed by transcript evidence
NP_001255373.1
  • Partially confirmed by transcript evidence
NP_001255374.1
  • Partially confirmed by transcript evidence
NP_001255375.1
  • Confirmed by transcript evidence
NP_001255376.1
  • Partially confirmed by transcript evidence
NP_001255377.1
  • Confirmed by transcript evidence
NP_001294032.1
  • Partially confirmed by transcript evidence
NP_001294033.1
  • Partially confirmed by transcript evidence
NP_001294035.1
  • Confirmed by transcript evidence
NP_001294036.1
  • Partially confirmed by transcript evidence
NP_001294037.1
  • Partially confirmed by transcript evidence
NP_001294038.1
  • Confirmed by transcript evidence
NP_001294039.1
  • Confirmed by transcript evidence
NP_001294040.1
  • Confirmed by transcript evidence
NP_001368092.1
  • Confirmed by transcript evidence
NP_001368454.1
  • Confirmed by transcript evidence
NP_501603.3
  • Confirmed by transcript evidence
NP_872075.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9200103..9212242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268441.4 → NP_001255370.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255370.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:335 → 596
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 660
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  2. NM_001307103.3 → NP_001294032.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294032.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H2L282, H2L283, H2L284, H2L285, H2L286, H2L288, H2L289, H2L290, H2L291, H2L292, H2L293, Q18657, Q8I127, X5LPT1, X5LPT5, X5LV40, X5LV44, X5LX64, X5M5N0, X5M5N6, X5M8T1, X5M8T5
    Conserved Domains (2) summary
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 686
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  3. NM_001380400.1 → NP_001368092.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 684
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  4. NM_001307107.3 → NP_001294036.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294036.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (2) summary
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 684
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  5. NM_001268439.4 → NP_001255368.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255368.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:335 → 596
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 660
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  6. NM_001380399.1 → NP_001368454.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 686
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  7. NM_182275.7 → NP_872075.2  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_872075.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:333 → 594
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 658
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  8. NM_001307109.4 → NP_001294038.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294038.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (2) summary
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 684
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  9. NM_069202.6 → NP_501603.3  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501603.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:333 → 594
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 658
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  10. NM_001307106.4 → NP_001294035.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294035.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (2) summary
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 686
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  11. NM_001307104.3 → NP_001294033.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294033.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (2) summary
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 686
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  12. NM_001268443.3 → NP_001255372.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255372.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:333 → 594
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 658
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  13. NM_001268442.4 → NP_001255371.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255371.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:335 → 596
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 660
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  14. NM_001307108.3 → NP_001294037.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294037.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (2) summary
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 684
    OSR1_C; Oxidative-stress-responsive kinase 1 C-terminal domain

  15. NM_001268440.3 → NP_001255369.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255369.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:335 → 596
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:332 → 596
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:622 → 660
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  16. NM_001268444.3 → NP_001255373.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255373.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:333 → 594
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:330 → 594
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:620 → 658
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  17. NM_001268445.3 → NP_001255374.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255374.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:282 → 543
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:279 → 543
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:569 → 607
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  18. NM_001268446.3 → NP_001255375.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255375.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:282 → 543
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:279 → 543
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:569 → 607
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  19. NM_001268447.3 → NP_001255376.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255376.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:280 → 541
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:277 → 541
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:567 → 605
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  20. NM_001268448.3 → NP_001255377.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255377.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
    Conserved Domains (3) summary
    smart00220
    Location:280 → 541
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd13983
    Location:277 → 541
    STKc_WNK; Catalytic domain of the Serine/Threonine kinase, With No Lysine (WNK) kinase
    pfam12202
    Location:567 → 605
    OSR1_C; Oxidative-stress-responsive kinase 1 C terminal

  21. NM_001307111.4 → NP_001294040.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294040.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0

  22. NM_001307110.3 → NP_001294039.1  Serine/threonine-protein kinase WNK [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001294039.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    X5M5N0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
X5M5N0.1

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