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vps-26 Vacuolar protein sorting-associated protein 26 [ Caenorhabditis elegans ]

Gene ID: 177764, updated on 2-Nov-2024

Summary

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Official Symbol
vps-26
Official Full Name
Vacuolar protein sorting-associated protein 26
Primary source
WormBase:WBGene00006931
Locus tag
CELE_T20D3.7
See related
AllianceGenome:WB:WBGene00006931
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in intracellular protein transport and retrograde transport, endosome to Golgi. Located in cytosol. Human ortholog(s) of this gene implicated in diabetic retinopathy and type 2 diabetes mellitus. Orthologous to several human genes including VPS26B (VPS26 retromer complex component B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See vps-26 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (9339400..9341790, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Solute carrier family 25 member 51 Neighboring gene HIG1 domain-containing protein Neighboring gene Phosphatidylinositol N-acetylglucosaminyltransferase subunit C Neighboring gene Piezo-type mechanosensitive ion channel component 1 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The retromer complex regulates C. elegans development and mammalian ciliogenesis. Xie S, et al. J Cell Sci, 2022 May 15. PMID 35510502, Free PMC Article
  2. The Mitochondrial Unfolded Protein Response Is Mediated Cell-Non-autonomously by Retromer-Dependent Wnt Signaling. Zhang Q, et al. Cell, 2018 Aug 9. PMID 30057120, Free PMC Article
  3. Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Lu N, et al. Mol Biol Cell, 2011 Feb 1. PMID 21148288, Free PMC Article
  4. Wnt gradient formation requires retromer function in Wnt-producing cells. Coudreuse DY, et al. Science, 2006 May 12. PMID 16645052
  5. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. Kanamori T, et al. EMBO J, 2008 Jun 18. PMID 18497747, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in retrograde transport, endosome to Golgi IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of retromer complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Vacuolar protein sorting-associated protein 26
NP_001129871.1
  • Confirmed by transcript evidence
NP_001263763.1
  • Confirmed by transcript evidence
NP_001380127.1
  • Confirmed by transcript evidence
NP_501644.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9339400..9341790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069243.5 → NP_501644.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501644.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01258
    Conserved Domains (1) summary
    pfam03643
    Location:59 → 334
    Vps26; Vacuolar protein sorting-associated protein 26

  2. NM_001276834.3 → NP_001263763.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263763.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    L8E917
    Conserved Domains (1) summary
    pfam03643
    Location:59 → 336
    Vps26; Vacuolar protein sorting-associated protein 26

  3. NM_001136399.3 → NP_001129871.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129871.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O01258
    UniProtKB/TrEMBL
    B3GWB9
    Conserved Domains (1) summary
    pfam03643
    Location:7 → 282
    Vps26; Vacuolar protein sorting-associated protein 26

  4. NM_001392366.1 → NP_001380127.1  Vacuolar protein sorting-associated protein 26 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    L8E6W6
    Conserved Domains (1) summary
    pfam03643
    Location:7 → 284
    Vps26; Vacuolar protein sorting-associated protein 26
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O01258.2

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