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daf-15 Raptor N-terminal CASPase-like domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177770, updated on 2-Nov-2024

Summary

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Official Symbol
daf-15
Official Full Name
Raptor N-terminal CASPase-like domain-containing protein
Primary source
WormBase:WBGene00000911
Locus tag
CELE_C10C5.6
See related
AllianceGenome:WB:WBGene00000911
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein kinase activator activity and protein-macromolecule adaptor activity. Involved in dauer larval development; determination of adult lifespan; and regulation of autophagosome assembly. Part of TORC1 complex. Is expressed in several structures, including body wall musculature; excretory cell; hermaphrodite distal tip cell; intestine; and pharyngeal muscle cell. Human ortholog(s) of this gene implicated in nicotine dependence. Orthologous to human RPTOR (regulatory associated protein of MTOR complex 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See daf-15 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
20
Sequence:
Chromosome: IV; NC_003282.8 (9386208..9394979)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene DUF4477 domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutants of Caenorhabditis elegans that form dauer-like larvae. Albert PS, et al. Dev Biol, 1988 Apr. PMID 3350212
  2. 10-Hydroxy-2-decenoic Acid, the Major Lipid Component of Royal Jelly, Extends the Lifespan of Caenorhabditis elegans through Dietary Restriction and Target of Rapamycin Signaling. Honda Y, et al. J Aging Res, 2015. PMID 25789174, Free PMC Article
  3. Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans. Zang X, et al. J Genet Genomics, 2024 May. PMID 37951302
  4. Lysosome Inhibition Reduces Basal and Nutrient-Induced Fat Accumulation in Caenorhabditis elegans. Lu R, et al. Mol Cells, 2022 Sep 30. PMID 36058890, Free PMC Article
  5. Sesamin extends lifespan through pathways related to dietary restriction in Caenorhabditis elegans. Nakatani Y, et al. Eur J Nutr, 2018 Apr. PMID 28239780

See all (50) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans.
    Title: Knockdown of neuronal DAF-15/Raptor promotes healthy aging in C. elegans.
  2. Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.
    Title: Mutually exclusive dendritic arbors in C. elegans neurons share a common architecture and convergent molecular cues.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein kinase activator activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein-macromolecule adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-macromolecule adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in TOR signaling IEA
Inferred from Electronic Annotation
more info
  
involved_in TORC1 signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to amino acid stimulus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of cell growth IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of autophagy IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of TORC1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of TORC1 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of TORC1 complex IEA
Inferred from Electronic Annotation
more info
  
part_of TORC1 complex ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Raptor N-terminal CASPase-like domain-containing protein
NP_001293857.1
  • Confirmed by transcript evidence
NP_001293858.1
  • Confirmed by transcript evidence
NP_001368188.1
  • Confirmed by transcript evidence
NP_001379099.1
  • Confirmed by transcript evidence
NP_501653.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9386208..9394979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380409.1 → NP_001368188.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q68TI8
    Conserved Domains (3) summary
    sd00044
    Location:834 → 866
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:1438 → 1495
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:92 → 246
    Raptor_N; Raptor N-terminal CASPase like domain

  2. NM_069252.7 → NP_501653.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEV7
    Conserved Domains (3) summary
    sd00044
    Location:810 → 842
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:1420 → 1477
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:68 → 222
    Raptor_N; Raptor N-terminal CASPase like domain

  3. NM_001306929.3 → NP_001293858.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293858.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6FD39
    Conserved Domains (3) summary
    sd00044
    Location:813 → 845
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:1423 → 1480
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:68 → 225
    Raptor_N; Raptor N-terminal CASPase like domain

  4. NM_001392368.1 → NP_001379099.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF88
    Conserved Domains (3) summary
    sd00044
    Location:810 → 842
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:1414 → 1471
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:68 → 222
    Raptor_N; Raptor N-terminal CASPase like domain

  5. NM_001306928.3 → NP_001293857.1  Raptor N-terminal CASPase-like domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293857.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    S6F588
    Conserved Domains (3) summary
    sd00044
    Location:813 → 845
    HEAT; HEAT repeat [structural motif]
    sd00039
    Location:1417 → 1474
    7WD40; WD40 repeat [structural motif]
    pfam14538
    Location:68 → 225
    Raptor_N; Raptor N-terminal CASPase like domain
Nucleotide Protein
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