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col-121 Nematode cuticle collagen N-terminal domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177771, updated on 2-Nov-2024

Summary

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Official Symbol
col-121
Official Full Name
Nematode cuticle collagen N-terminal domain-containing protein
Primary source
WormBase:WBGene00000695
Locus tag
CELE_F56D5.1
See related
AllianceGenome:WB:WBGene00000695
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be a structural constituent of cuticle. Predicted to be located in membrane. Predicted to be part of collagen trimer. Is expressed in hyp7 syncytium. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See col-121 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (9394873..9396218, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Raptor N-terminal CASPase-like domain-containing protein Neighboring gene DUF4477 domain-containing protein Neighboring gene NADH:flavin oxidoreductase/NADH oxidase N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Toxicogenomic responses to zearalenone in Caenorhabditis elegans reveal possible molecular mechanisms of reproductive toxicity. Yang Z, et al. Food Chem Toxicol, 2018 Dec. PMID 30292620
  2. A mutation in a cuticle collagen causes hypersensitivity to the endocrine disrupting chemical, bisphenol A, in Caenorhabditis elegans. Watanabe M, et al. Mutat Res, 2005 Feb 15. PMID 15680404
  3. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables structural constituent of cuticle IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of collagen trimer IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nematode cuticle collagen N-terminal domain-containing protein
NP_501655.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9394873..9396218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069254.5 → NP_501655.1  Nematode cuticle collagen N-terminal domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501655.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q20880
    Conserved Domains (2) summary
    pfam01391
    Location:143 → 200
    Collagen; Collagen triple helix repeat (20 copies)
    smart01088
    Location:10 → 60
    Col_cuticle_N; Nematode cuticle collagen N-terminal domain
Nucleotide Protein
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