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hsp-12.6 SHSP domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177778, updated on 2-Nov-2024

Summary

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Official Symbol
hsp-12.6
Official Full Name
SHSP domain-containing protein
Primary source
WormBase:WBGene00002013
Locus tag
CELE_F38E11.2
See related
AllianceGenome:WB:WBGene00002013
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables identical protein binding activity. Predicted to be involved in protein refolding and response to heat. Located in cytoplasm. Is expressed in hypodermis; intestine; muscle cell; sperm; and spermatid. Human ortholog(s) of this gene implicated in cataract 16 multiple types; cataract 9 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAA (crystallin alpha A); CRYAB (crystallin alpha B); and HSPB6 (heat shock protein family B (small) member 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hsp-12.6 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
3
Sequence:
Chromosome: IV; NC_003282.8 (9446229..9447228, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene SHSP domain-containing protein Neighboring gene ncRNA Neighboring gene PAN domain protein Neighboring gene Amidohydrolase-related domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Investigating hookworm genomes by comparative analysis of two Ancylostoma species. Mitreva M, et al. BMC Genomics, 2005 Apr 26. PMID 15854223, Free PMC Article
  2. Confocal spectrofluorimetric evidence for the hetero-aggregation of sequence-scrambled forms of two model all-beta sheet proteins. Shukla A, et al. Int J Biol Macromol, 2007 Dec 1. PMID 17707903
  3. Unique structural features of a novel class of small heat shock proteins. Leroux MR, et al. J Biol Chem, 1997 May 9. PMID 9139746
  4. Neuroprotective Effects of 2-Substituted 1, 3-Selenazole Amide Derivatives on Amyloid-Beta-Induced Toxicity in a Transgenic Caenorhabditis Elegans Model of Alzheimer's Disease. Wang H, et al. Neurotox Res, 2021 Jun. PMID 33400180
  5. Association of several small heat-shock proteins with reproductive tissues in the nematode Caenorhabditis elegans. Ding L, et al. Biochem J, 2000 Oct 1. PMID 11001875, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Caenorhabditis elegans 12-kDa small heat shock proteins with little in vitro chaperone activity play crucial roles for its dauer formation, longevity, and reproduction.
    Title: The Caenorhabditis elegans 12-kDa small heat shock proteins with little in vitro chaperone activity play crucial roles for its dauer formation, longevity, and reproduction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
NOT enables unfolded protein binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein refolding IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to heat IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
SHSP domain-containing protein
NP_501668.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9446229..9447228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069267.4 → NP_501668.1  SHSP domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501668.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EE36
    Conserved Domains (1) summary
    cd06526
    Location:27 → 108
    metazoan_ACD; Alpha-crystallin domain (ACD) of metazoan alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are ...
Nucleotide Protein
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