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elo-1 Long chain fatty acid elongase 1 [ Caenorhabditis elegans ]

Gene ID: 177787, updated on 2-Nov-2024

Summary

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Official Symbol
elo-1
Official Full Name
Long chain fatty acid elongase 1
Primary source
WormBase:WBGene00001239
Locus tag
CELE_F56H11.4
See related
AllianceGenome:WB:WBGene00001239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable fatty acid elongase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including body wall musculature; enteric muscle; intestine; pharynx; and rectal gland cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See elo-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (9526366..9528336)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene putative NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Elongation of very long chain fatty acids protein Neighboring gene DUF202 domain-containing protein;Secreted protein;Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Heterologous reconstitution in yeast of the polyunsaturated fatty acid biosynthetic pathway. Beaudoin F, et al. Proc Natl Acad Sci U S A, 2000 Jun 6. PMID 10829069, Free PMC Article
  2. Suppression of the ELO-2 FA elongation activity results in alterations of the fatty acid composition and multiple physiological defects, including abnormal ultradian rhythms, in Caenorhabditis elegans. Kniazeva M, et al. Genetics, 2003 Jan. PMID 12586704, Free PMC Article
  3. A Saccharomyces cerevisiae gene required for heterologous fatty acid elongase activity encodes a microsomal beta-keto-reductase. Beaudoin F, et al. J Biol Chem, 2002 Mar 29. PMID 11792704
  4. Genetic dissection of polyunsaturated fatty acid synthesis in Caenorhabditis elegans. Watts JL, et al. Proc Natl Acad Sci U S A, 2002 Apr 30. PMID 11972048, Free PMC Article
  5. Juniperonic Acid Biosynthesis is Essential in Caenorhabditis Elegans Lacking Δ6 Desaturase (fat-3) and Generates New ω-3 Endocannabinoids. Guha S, et al. Cells, 2020 Sep 19. PMID 32961767, Free PMC Article

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables fatty acid elongase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acid elongase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cellular lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid elongation, monounsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, polyunsaturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in fatty acid elongation, saturated fatty acid IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in lipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingolipid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in unsaturated fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in very long-chain fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Long chain fatty acid elongase 1
NP_001263767.1
  • Partially confirmed by transcript evidence
NP_501689.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9526366..9528336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069288.9 → NP_501689.1  Long chain fatty acid elongase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501689.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EEE5, K8ES54
    Conserved Domains (1) summary
    pfam01151
    Location:39 → 278
    ELO; GNS1/SUR4 family

  2. NM_001276838.3 → NP_001263767.1  Long chain fatty acid elongase 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263767.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ES54
    Conserved Domains (1) summary
    pfam01151
    Location:1 → 224
    ELO; GNS1/SUR4 family
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EEE5.1

Gene LinkOut

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