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cka-1 Choline/ethanolamine kinase [ Caenorhabditis elegans ]

Gene ID: 177807, updated on 2-Nov-2024

Summary

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Official Symbol
cka-1
Official Full Name
Choline/ethanolamine kinase
Primary source
WormBase:WBGene00000509
Locus tag
CELE_C28D4.2
See related
AllianceGenome:WB:WBGene00000509
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables choline kinase activity. Involved in CDP-choline pathway. Located in cell cortex. Human ortholog(s) of this gene implicated in intellectual disability; megaconial type congenital muscular dystrophy; muscular dystrophy; narcolepsy; and recurrent hypersomnia. Orthologous to human CHKA (choline kinase alpha) and CHKB (choline kinase beta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cka-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
11
Sequence:
Chromosome: IV; NC_003282.8 (9731737..9737621, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Nuclear Hormone Receptor family Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-100 Neighboring gene Ubiquitin-like domain-containing protein Neighboring gene glutamine synthetase Neighboring gene DUF1248 domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134025
  2. A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134024
  3. Multiple isoforms of choline kinase from Caenorhabditis elegans: cloning, expression, purification, and characterization. Gee P, et al. Biochim Biophys Acta, 2003 May 30. PMID 12758145
  4. Protein kinase C isotypes in C. elegans. Tabuse Y. J Biochem, 2002 Oct. PMID 12359064
  5. A conserved megaprotein-based molecular bridge critical for lipid trafficking and cold resilience. Wang C, et al. Nat Commun, 2022 Nov 10. PMID 36357390, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables choline kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables choline kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ethanolamine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in CDP-choline pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in CDP-choline pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in phosphatidylethanolamine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Choline/ethanolamine kinase
NP_001129849.1
  • Confirmed by transcript evidence
NP_001293883.1
  • Partially confirmed by transcript evidence
NP_501732.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9731737..9737621 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069331.4 → NP_501732.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501732.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O17610
    Conserved Domains (2) summary
    PLN02236
    Location:100 → 467
    PLN02236; choline kinase
    cd05156
    Location:112 → 465
    ChoK_euk; Euykaryotic Choline Kinase

  2. NM_001306954.3 → NP_001293883.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001293883.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A061AIW1
    Conserved Domains (2) summary
    PLN02236
    Location:74 → 444
    PLN02236; choline kinase
    cd05156
    Location:86 → 442
    ChoK_euk; Euykaryotic Choline Kinase

  3. NM_001136377.4 → NP_001129849.1  Choline/ethanolamine kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129849.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B3GWD5
    Conserved Domains (2) summary
    PLN02236
    Location:74 → 441
    PLN02236; choline kinase
    cd05156
    Location:86 → 439
    ChoK_euk; Euykaryotic Choline Kinase
Nucleotide Protein
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