fat-4 Delta(5) fatty acid desaturase fat-4 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: fat-4
Official Full Name: Delta(5) fatty acid desaturase fat-4
Primary source: WormBase:WBGene00001396
Locus tag: CELE_T13F2.1
See related: AllianceGenome:WB:WBGene00001396
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables stearoyl-CoA 9-desaturase activity. Involved in unsaturated fatty acid biosynthetic process. Predicted to be located in membrane. Is expressed in intestine; nerve ring; and touch receptor neurons. Used to study alcohol use disorder. Orthologous to several human genes including FADS1 (fatty acid desaturase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fat-4 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 8

Sequence:: Chromosome: IV; NC_003282.8 (9799429..9802226)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T13F2.1 (e-PCR)
- UniSTS:310834

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables acyl-CoA delta5-desaturase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water	IBA Inferred from Biological aspect of Ancestor more info
enables stearoyl-CoA 9-desaturase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info
involved_in unsaturated fatty acid biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in unsaturated fatty acid biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Delta(5) fatty acid desaturase fat-4

NP_001255423.1

Partially confirmed by transcript evidence

NP_001255424.1

Partially confirmed by transcript evidence

NP_001255425.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

9799429..9802226

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268494.2 → NP_001255423.1 Delta(5) fatty acid desaturase fat-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255423.1

Status: REVIEWED

UniProtKB/Swiss-Prot

D5MCT8, E9P887, G5EG11

Conserved Domains (2) summary

cd03506
Location:153 → 414

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00487
Location:152 → 417

FA_desaturase; Fatty acid desaturase
NM_001268495.3 → NP_001255424.1 Delta(5) fatty acid desaturase fat-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255424.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG11

Conserved Domains (2) summary

cd03506
Location:62 → 323

Delta6-FADS-like; The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases ...

pfam00487
Location:61 → 326

FA_desaturase; Fatty acid desaturase
NM_001268496.3 → NP_001255425.1 Delta(5) fatty acid desaturase fat-4 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255425.1

Status: REVIEWED

UniProtKB/Swiss-Prot

G5EG11

Conserved Domains (1) summary

cl00615
Location:1 → 22

Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...