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npp-1 Nucleoporin Nup54 alpha-helical domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177836, updated on 2-Nov-2024

Summary

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Official Symbol
npp-1
Official Full Name
Nucleoporin Nup54 alpha-helical domain-containing protein
Primary source
WormBase:WBGene00003787
Locus tag
CELE_K07F5.13
See related
AllianceGenome:WB:WBGene00003787
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calmodulin binding activity. Involved in several processes, including establishment of mitotic spindle orientation; nuclear pore organization; and positive regulation of mitotic cell cycle, embryonic. Located in nuclear envelope. Is expressed in several structures, including hypodermis. Human ortholog(s) of this gene implicated in dystonia 37, early-onset with striatal lesions. Orthologous to human NUP54 (nucleoporin 54). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See npp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
10
Sequence:
Chromosome: IV; NC_003282.8 (9858488..9862119)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sperm-Specific family, class Q Neighboring gene Transmembrane protein 144 homolog Neighboring gene NUC153 domain-containing protein Neighboring gene J domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Channel Nucleoporins Recruit PLK-1 to Nuclear Pore Complexes to Direct Nuclear Envelope Breakdown in C. elegans. Martino L, et al. Dev Cell, 2017 Oct 23. PMID 29065307, Free PMC Article
  2. Nucleoporins NPP-1, NPP-3, NPP-4, NPP-11 and NPP-13 are required for proper spindle orientation in C. elegans. Schetter A, et al. Dev Biol, 2006 Jan 15. PMID 16325795, Free PMC Article
  3. Sensitized piRNA reporter identifies multiple RNA processing factors involved in piRNA-mediated gene silencing. Brown JS, et al. Genetics, 2023 Aug 9. PMID 37210214, Free PMC Article
  4. Age-related changes of nuclear architecture in Caenorhabditis elegans. Haithcock E, et al. Proc Natl Acad Sci U S A, 2005 Nov 15. PMID 16269543, Free PMC Article
  5. Mechanisms of nuclear pore complex disassembly by the mitotic Polo-like kinase 1 (PLK-1) in C. elegans embryos. Nkombo Nkoula S, et al. Sci Adv, 2023 Jul 21. PMID 37467327, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calmodulin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables structural constituent of nuclear pore IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in NLS-bearing protein import into nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in establishment of mitotic spindle orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nuclear pore organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nuclear pore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nucleus organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of mitotic cell cycle, embryonic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein localization to nuclear inner membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in reproductive process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear pore IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear pore central transport channel IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nucleoporin Nup54 alpha-helical domain-containing protein
NP_001379121.1
  • Partially confirmed by transcript evidence
NP_501770.1
  • Confirmed by transcript evidence
NP_501771.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9858488..9862119
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069369.5 → NP_501770.1  Nucleoporin Nup54 alpha-helical domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501770.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3B9
    Conserved Domains (3) summary
    pfam13634
    Location:2 → 106
    Nucleoporin_FG; Nucleoporin FG repeat region
    pfam13874
    Location:443 → 574
    Nup54; Nucleoporin complex subunit 54
    pfam15967
    Location:83 → 219
    Nucleoporin_FG2; Nucleoporin FG repeated region

  2. NM_069370.5 → NP_501771.1  Nucleoporin Nup54 alpha-helical domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501771.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3C1
    Conserved Domains (2) summary
    pfam13634
    Location:2 → 122
    Nucleoporin_FG; Nucleoporin FG repeat region
    pfam13874
    Location:353 → 484
    Nup54; Nucleoporin complex subunit 54

  3. NM_001392375.1 → NP_001379121.1  Nucleoporin Nup54 alpha-helical domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21295, Q21296
    Conserved Domains (3) summary
    pfam13634
    Location:49 → 132
    Nucleoporin_FG; Nucleoporin FG repeat region
    pfam13874
    Location:416 → 550
    Nup54; Nucleoporin complex subunit 54
    pfam15967
    Location:62 → 262
    Nucleoporin_FG2; Nucleoporin FG repeated region
Nucleotide Protein
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