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nhr-4 Nuclear hormone receptor family member nhr-4 [ Caenorhabditis elegans ]

Gene ID: 177839, updated on 2-Nov-2024

Summary

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Official Symbol
nhr-4
Official Full Name
Nuclear hormone receptor family member nhr-4
Primary source
WormBase:WBGene00003603
Locus tag
CELE_F32B6.1
See related
AllianceGenome:WB:WBGene00003603
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. Is expressed in intestine; nervous system; pharynx; and tail. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See nhr-4 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (9879329..9882152)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Pre-mRNA-splicing factor 18 Neighboring gene ncRNA Neighboring gene Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial Neighboring gene non-specific serine/threonine protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The nuclear receptor superfamily has undergone extensive proliferation and diversification in nematodes. Sluder AE, et al. Genome Res, 1999 Feb. PMID 10022975
  2. A genome-wide map of conserved microRNA targets in C. elegans. Lall S, et al. Curr Biol, 2006 Mar 7. PMID 16458514
  3. The molecular signature and cis-regulatory architecture of a C. elegans gustatory neuron. Etchberger JF, et al. Genes Dev, 2007 Jul 1. PMID 17606643, Free PMC Article
  4. The C. elegans regulatory factor X (RFX) DAF-19M module: A shift from general ciliogenesis to cell-specific ciliary and behavioral specialization. Ahn S, et al. Cell Rep, 2022 Apr 12. PMID 35417689
  5. Extensive rewiring and complex evolutionary dynamics in a C. elegans multiparameter transcription factor network. Reece-Hoyes JS, et al. Mol Cell, 2013 Jul 11. PMID 23791784, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Nuclear hormone receptor family member nhr-4
NP_501775.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9879329..9882152
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069374.11 → NP_501775.1  Nuclear hormone receptor family member nhr-4 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45436
    Conserved Domains (2) summary
    cd06157
    Location:280 → 451
    NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators
    cd06960
    Location:50 → 125
    NR_DBD_HNF4A; DNA-binding domain of heptocyte nuclear factor 4 (HNF4) is composed of two C4-type zinc fingers
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45436.2

Gene LinkOut

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