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prp-18 Pre-mRNA-splicing factor 18 [ Caenorhabditis elegans ]

Gene ID: 177840, updated on 2-Nov-2024

Summary

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Official Symbol
prp-18
Official Full Name
Pre-mRNA-splicing factor 18
Primary source
WormBase:WBGene00009320
Locus tag
CELE_F32B6.3
See related
AllianceGenome:WB:WBGene00009320
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in generation of catalytic spliceosome for second transesterification step. Predicted to be located in nucleus. Predicted to be part of U2-type post-spliceosomal complex; U4/U6 x U5 tri-snRNP complex; and U5 snRNP. Orthologous to human PRPF18 (pre-mRNA processing factor 18). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See prp-18 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (9882132..9884383, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-4 Neighboring gene ncRNA Neighboring gene Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial Neighboring gene non-specific serine/threonine protein kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Using RNA interference to identify specific modifiers of a temperature-sensitive, embryonic-lethal mutation in the Caenorhabditis elegans ubiquitin-like Nedd8 protein modification pathway E1-activating gene rfl-1. Dorfman M, et al. Genetics, 2009 Aug. PMID 19528325, Free PMC Article
  2. A whole-genome RNAi Screen for C. elegans miRNA pathway genes. Parry DH, et al. Curr Biol, 2007 Dec 4. PMID 18023351, Free PMC Article
  3. A modified TurboID approach identifies tissue-specific centriolar components in C. elegans. Holzer E, et al. PLoS Genet, 2022 Apr. PMID 35442950, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in generation of catalytic spliceosome for second transesterification step IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of U2-type post-spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U5 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Pre-mRNA-splicing factor 18
NP_501776.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9882132..9884383 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069375.7 → NP_501776.2  Pre-mRNA-splicing factor 18 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501776.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45431
    Conserved Domains (2) summary
    smart00500
    Location:85 → 128
    SFM; Splicing Factor Motif, present in Prp18 and Pr04
    pfam02840
    Location:199 → 336
    Prp18; Prp18 domain
Nucleotide Protein
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