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mccc-1 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 177841, updated on 2-Nov-2024

Summary

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Official Symbol
mccc-1
Official Full Name
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
Primary source
WormBase:WBGene00009319
Locus tag
CELE_F32B6.2
See related
AllianceGenome:WB:WBGene00009319
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and ligase activity. Predicted to contribute to methylcrotonoyl-CoA carboxylase activity. Predicted to be active in mitochondrion. Is expressed in several structures, including anal depressor muscle; egg-laying apparatus; intestine; nervous system; and rectal gland cell. Human ortholog(s) of this gene implicated in 3-methylcrotonyl-CoA carboxylase 1 deficiency. Orthologous to human MCCC1 (methylcrotonyl-CoA carboxylase subunit 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mccc-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (9884570..9887151)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Nuclear hormone receptor family member nhr-4 Neighboring gene Pre-mRNA-splicing factor 18 Neighboring gene ncRNA Neighboring gene non-specific serine/threonine protein kinase Neighboring gene SH2 domain-containing protein Neighboring gene Sperm-Specific family, class S

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Wirth M, et al. Mitochondrion, 2013 Nov. PMID 23438705, Free PMC Article
  2. Integration of metabolic and gene regulatory networks modulates the C. elegans dietary response. Watson E, et al. Cell, 2013 Mar 28. PMID 23540702, Free PMC Article
  3. Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system. Segref A, et al. Cell Metab, 2014 Apr 1. PMID 24703696
  4. SKIP and BIR-1/Survivin have potential to integrate proteome status with gene expression. Kostrouch D, et al. J Proteomics, 2014 Oct 14. PMID 25088050
  5. Gene regulatory network inference in long-lived C. elegans reveals modular properties that are predictive of novel aging genes. Suriyalaksh M, et al. iScience, 2022 Jan 21. PMID 35036864, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
contributes_to methylcrotonoyl-CoA carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial
NP_501777.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9884570..9887151
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069376.8 → NP_501777.2  Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501777.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45430
    Conserved Domains (5) summary
    cd06850
    Location:606 → 670
    biotinyl_domain; The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase, ...
    COG4770
    Location:19 → 671
    PccA; Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid transport and metabolism]
    pfam00289
    Location:19 → 127
    CPSase_L_chain; Carbamoyl-phosphate synthase L chain, N-terminal domain
    pfam02785
    Location:353 → 457
    Biotin_carb_C; Biotin carboxylase C-terminal domain
    cl17255
    Location:133 → 339
    ATP-grasp_4; ATP-grasp domain
Nucleotide Protein
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Gene LinkOut

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