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tbc-3 Rab-GAP TBC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177845, updated on 2-Nov-2024

Summary

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Official Symbol
tbc-3
Official Full Name
Rab-GAP TBC domain-containing protein
Primary source
WormBase:WBGene00009322
Locus tag
CELE_F32B6.8
See related
AllianceGenome:WB:WBGene00009322
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable GTPase activator activity. Located in Golgi apparatus. Is expressed in hermaphrodite distal tip cell; neurons; pharynx; rect_D; and seam cell. Orthologous to human TBC1D22A (TBC1 domain family member 22A) and TBC1D22B (TBC1 domain family member 22B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tbc-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (9899012..9902513)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Bestrophin homolog 13 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Distinct pathways for export of silencing RNA in Caenorhabditis elegans systemic RNAi. Yoshida K, et al. iScience, 2023 Oct 20. PMID 37854694, Free PMC Article
  2. MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications. Artan M, et al. Autophagy, 2022 May. PMID 35188063, Free PMC Article
  3. Beta-catenin asymmetry is regulated by PLA1 and retrograde traffic in C. elegans stem cell divisions. Kanamori T, et al. EMBO J, 2008 Jun 18. PMID 18497747, Free PMC Article
  4. The long and the short of Wnt signaling in C. elegans. Hardin J, et al. Curr Opin Genet Dev, 2008 Aug. PMID 18625312, Free PMC Article
  5. Depletion of endogenously biotinylated carboxylases enhances the sensitivity of TurboID-mediated proximity labeling in Caenorhabditis elegans. Artan M, et al. J Biol Chem, 2022 Sep. PMID 35933017, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTPase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Rab-GAP TBC domain-containing protein
NP_001023164.1
  • Confirmed by transcript evidence
NP_001023165.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    9899012..9902513
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001027993.4 → NP_001023164.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023164.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JL36
    Conserved Domains (1) summary
    smart00164
    Location:170 → 421
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

  2. NM_001027994.4 → NP_001023165.1  Rab-GAP TBC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023165.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45434
    Conserved Domains (1) summary
    smart00164
    Location:190 → 441
    TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs
Nucleotide Protein
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