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ipla-7 PNPLA domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 177869, updated on 2-Nov-2024

Summary

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Official Symbol
ipla-7
Official Full Name
PNPLA domain-containing protein
Primary source
WormBase:WBGene00011423
Locus tag
CELE_T04B2.5
See related
AllianceGenome:WB:WBGene00011423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium-independent phospholipase A2 activity and long-chain fatty acyl-CoA hydrolase activity. Predicted to be involved in positive regulation of ceramide biosynthetic process. Predicted to be active in mitochondrion. Is expressed in intestine; pharyngeal-intestinal valve; pharynx; virL; and virR. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ipla-7 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (10056591..10059178, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein Neighboring gene ncRNA Neighboring gene DUF2780 domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Protein Wnt-2 Neighboring gene MFS domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Muscle-Specific Lipid Hydrolysis Prolongs Lifespan through Global Lipidomic Remodeling. Schmeisser S, et al. Cell Rep, 2019 Dec 24. PMID 31875559
  2. Roles of acidic phospholipids and nucleotides in regulating membrane binding and activity of a calcium-independent phospholipase A2 isoform. Morrison K, et al. J Biol Chem, 2012 Nov 9. PMID 23007400, Free PMC Article
  3. Regulation of tissue-specific and extracellular matrix-related genes by a class I histone deacetylase. Whetstine JR, et al. Mol Cell, 2005 May 13. PMID 15893731
  4. Screening for cold tolerance genes in C. elegans, whose expressions are affected by anticancer drugs camptothecin and leptomycin B. Okahata M, et al. Sci Rep, 2024 Mar 5. PMID 38443452, Free PMC Article
  5. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
PNPLA domain-containing protein
NP_001369902.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10056591..10059178 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383178.1 → NP_001369902.1  PNPLA domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF58
    Conserved Domains (1) summary
    cl11396
    Location:141 → 442
    Patatin_and_cPLA2; Patatins and Phospholipases
Nucleotide Protein
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