U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

dis-3 putative exosome complex exonuclease RRP44 [ Caenorhabditis elegans ]

Gene ID: 177875, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
dis-3
Official Full Name
putative exosome complex exonuclease RRP44
Primary source
WormBase:WBGene00001001
Locus tag
CELE_C04G2.6
See related
AllianceGenome:WB:WBGene00001001
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable 3'-5'-RNA exonuclease activity and endonuclease activity. Predicted to be involved in nuclear mRNA surveillance of mRNA 3'-end processing and rRNA catabolic process. Predicted to be located in nucleoplasm. Predicted to be part of cytoplasmic exosome (RNase complex) and nuclear exosome (RNase complex). Is expressed in several structures, including anal depressor muscle; excretory cell; hypodermis; nervous system; and reproductive system. Orthologous to human DIS3 (DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See dis-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
13
Sequence:
Chromosome: IV; NC_003282.8 (10097202..10106523)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene BTB domain-containing protein Neighboring gene Major sperm protein 10/36/56/76 Neighboring gene Paired box protein 5 homolog Neighboring gene SPerm CHromatin enriched

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. U-tail as a guardian against invading RNAs. Yeo J, et al. Nat Struct Mol Biol, 2018 Oct. PMID 30242214
  2. Origins of recently gained introns in Caenorhabditis. Coghlan A, et al. Proc Natl Acad Sci U S A, 2004 Aug 3. PMID 15243155, Free PMC Article
  3. Collaborative Control of Cell Cycle Progression by the RNA Exonuclease Dis3 and Ras Is Conserved Across Species. Snee MJ, et al. Genetics, 2016 Jun. PMID 27029730, Free PMC Article
  4. A modular network model of aging. Xue H, et al. Mol Syst Biol, 2007. PMID 18059442, Free PMC Article
  5. A ZTF-7/RPS-2 complex mediates the cold-warm response in C. elegans. Xu T, et al. PLoS Genet, 2023 Feb. PMID 36763670, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables 3'-5'-RNA exonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables RNA nuclease activity IEA
Inferred from Electronic Annotation
more info
  
enables endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables exonuclease activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nuclear mRNA surveillance of mRNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of cytoplasmic exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of exosome (RNase complex) IEA
Inferred from Electronic Annotation
more info
  
part_of nuclear exosome (RNase complex) IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
putative exosome complex exonuclease RRP44
NP_501835.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10097202..10106523
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069434.6 → NP_501835.2  putative exosome complex exonuclease RRP44 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501835.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q17632
    Conserved Domains (3) summary
    TIGR00358
    Location:271 → 940
    3_prime_RNase; VacB and RNase II family 3'-5' exoribonucleases
    pfam00773
    Location:479 → 809
    RNB; RNB domain
    cl14812
    Location:21 → 202
    PIN_SF; PIN (PilT N terminus) domain: Superfamily
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17632.2

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous