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gtbp-1 Ras GTPase-activating protein-binding protein gtbp-1 [ Caenorhabditis elegans ]

Gene ID: 177880, updated on 2-Nov-2024

Summary

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Official Symbol
gtbp-1
Official Full Name
Ras GTPase-activating protein-binding protein gtbp-1
Primary source
WormBase:WBGene00010677
Locus tag
CELE_K08F4.2
See related
AllianceGenome:WB:WBGene00010677
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable mRNA binding activity. Predicted to be involved in stress granule assembly. Located in cytoplasmic stress granule. Is expressed widely. Orthologous to human G3BP1 (G3BP stress granule assembly factor 1) and G3BP2 (G3BP stress granule assembly factor 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gtbp-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10126749..10128956, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Receptor L-domain domain-containing protein Neighboring gene AAA+ ATPase domain-containing protein Neighboring gene ncRNA Neighboring gene Translocon-associated protein subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans. Paix A, et al. Genetics, 2014 Dec. PMID 25249454, Free PMC Article
  2. Quantitative phosphoproteomics reveals GTBP-1 regulating C.elegans lifespan at different environmental temperatures. Huang J, et al. Biochem Biophys Res Commun, 2018 Sep 10. PMID 30078680
  3. PQN-59 and GTBP-1 contribute to stress granule formation but are not essential for their assembly in C. elegans embryos. Abbatemarco S, et al. J Cell Sci, 2021 Nov 15. PMID 34661238, Free PMC Article
  4. G3BP1-dependent mechanism suppressing protein aggregation in Huntington's models and its demise upon stress granule assembly. Gutiérrez-Garcia R, et al. Hum Mol Genet, 2023 May 5. PMID 36611004, Free PMC Article
  5. Targeting the NEDP1 enzyme to ameliorate ALS phenotypes through stress granule disassembly. Kassouf T, et al. Sci Adv, 2023 Mar 31. PMID 37000881, Free PMC Article

See all (21) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. PQN-59 and GTBP-1 contribute to stress granule formation but are not essential for their assembly in C. elegans embryos.
    Title: PQN-59 and GTBP-1 contribute to stress granule formation but are not essential for their assembly in C. elegans embryos.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in stress granule assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic stress granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasmic stress granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in intracellular organelle IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Ras GTPase-activating protein-binding protein gtbp-1
NP_501842.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10126749..10128956 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069441.9 → NP_501842.2  Ras GTPase-activating protein-binding protein gtbp-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501842.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21351
    Conserved Domains (2) summary
    cd00780
    Location:33 → 145
    NTF2; Nuclear transport factor 2 (NTF2) domain plays an important role in the trafficking of macromolecules, ions and small molecules between the cytoplasm and nucleus. This bi-directional transport of macromolecules across the nuclear envelope requires many ...
    cl17169
    Location:326 → 404
    RRM_SF; RNA recognition motif (RRM) superfamily
Nucleotide Protein
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