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mspn-1 Mitochondrial sorting homolog [ Caenorhabditis elegans ]

Gene ID: 177896, updated on 2-Nov-2024

Summary

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Official Symbol
mspn-1
Official Full Name
Mitochondrial sorting homolog
Primary source
WormBase:WBGene00010557
Locus tag
CELE_K04D7.2
See related
AllianceGenome:WB:WBGene00010557
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable ATP binding activity and ATP hydrolysis activity. Predicted to be involved in extraction of mislocalized protein from mitochondrial outer membrane. Predicted to be located in mitochondrion. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in hyperekplexia 4. Orthologous to human ATAD1 (ATPase family AAA domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mspn-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
5
Sequence:
Chromosome: IV; NC_003282.8 (10177968..10180301)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Small ribosomal subunit protein RACK1 Neighboring gene putative 4-aminobutyrate aminotransferase, mitochondrial Neighboring gene Tyrosine-protein phosphatase 4 Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Msp1 cooperates with the proteasome for extraction of arrested mitochondrial import intermediates. Basch M, et al. Mol Biol Cell, 2020 Apr 1. PMID 32049577, Free PMC Article
  2. SIN-3 acts in distinct complexes to regulate the germline transcriptional program in Caenorhabditis elegans. Robert VJ, et al. Development, 2023 Nov 1. PMID 37818613, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in extraction of mislocalized protein from mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mitochondrial sorting homolog
NP_501860.1
  • Confirmed by transcript evidence
NP_501861.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10177968..10180301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069459.9 → NP_501860.1  Mitochondrial sorting homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501860.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54815, Q95ZR8
    Conserved Domains (2) summary
    smart00382
    Location:116 → 244
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:120 → 249
    AAA; ATPase family associated with various cellular activities (AAA)

  2. NM_069460.3 → NP_501861.1  Mitochondrial sorting homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501861.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P54815
    Conserved Domains (3) summary
    smart00382
    Location:113 → 241
    AAA; ATPases associated with a variety of cellular activities
    pfam00004
    Location:117 → 246
    AAA; ATPase family associated with various cellular activities (AAA)
    cl09176
    Location:41 → 124
    FlgN; FlgN protein
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P54815.2

Gene LinkOut

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