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tram-1 Translocating chain-associated membrane protein [ Caenorhabditis elegans ]

Gene ID: 177902, updated on 2-Nov-2024

Summary

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Official Symbol
tram-1
Official Full Name
Translocating chain-associated membrane protein
Primary source
WormBase:WBGene00007696
Locus tag
CELE_C24F3.1
See related
AllianceGenome:WB:WBGene00007696
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in SRP-dependent cotranslational protein targeting to membrane, translocation and protein insertion into ER membrane. Located in dendrite terminus; periciliary membrane compartment; and rough endoplasmic reticulum. Is expressed in body wall musculature. Orthologous to human TRAM1 (translocation associated membrane protein 1); TRAM1L1 (translocation associated membrane protein 1 like 1); and TRAM2 (translocation associated membrane protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tram-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (10219373..10221287, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Serpentine receptor class gamma Neighboring gene ABC transporter domain-containing protein Neighboring gene Glutamine-dependent NAD(+) synthetase;NAD/GMP synthase domain-containing protein Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene ncRNA Neighboring gene protein-tyrosine-phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic analysis of hyl-1, the C. elegans homolog of LAG1/LASS1. Tedesco P, et al. Age (Dordr), 2008 Mar. PMID 19424872, Free PMC Article
  2. Targeting of rough endoplasmic reticulum membrane proteins and ribosomes in invertebrate neurons. Rolls MM, et al. Mol Biol Cell, 2002 May. PMID 12006669, Free PMC Article
  3. Innovative fluorescent probes for in vivo visualization of biomolecules in living Caenorhabditis elegans. Wang C, et al. Cytometry A, 2021 Jun. PMID 33638604
  4. CDKL Family Kinases Have Evolved Distinct Structural Features and Ciliary Function. Canning P, et al. Cell Rep, 2018 Jan 23. PMID 29420175, Free PMC Article
  5. Interpreting the pathogenicity of Joubert syndrome missense variants in Caenorhabditis elegans. Lange KI, et al. Dis Model Mech, 2021 Jan 1. PMID 33234550, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation IEA
Inferred from Electronic Annotation
more info
  
involved_in SRP-dependent cotranslational protein targeting to membrane, translocation ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in dendrite terminus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in periciliary membrane compartment IDA
Inferred from Direct Assay
more info
 PubMed 
located_in rough endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Translocating chain-associated membrane protein
NP_501868.1
  • Confirmed by transcript evidence
NP_501869.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10219373..10221287 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069468.4 → NP_501869.1  Translocating chain-associated membrane protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501869.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U3P5
    Conserved Domains (2) summary
    pfam03798
    Location:124 → 308
    TRAM_LAG1_CLN8; TLC domain
    pfam08390
    Location:53 → 119
    TRAM1; TRAM1-like protein

  2. NM_069467.7 → NP_501868.1  Translocating chain-associated membrane protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_501868.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXK7
    Conserved Domains (2) summary
    pfam03798
    Location:124 → 310
    TRAM_LAG1_CLN8; TLC domain
    pfam08390
    Location:53 → 119
    TRAM1; TRAM1-like protein
Nucleotide Protein
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