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daf-14 Smad-related protein daf-14 [ Caenorhabditis elegans ]

Gene ID: 177908, updated on 2-Nov-2024

Summary

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Official Symbol
daf-14
Official Full Name
Smad-related protein daf-14
Primary source
WormBase:WBGene00000910
Locus tag
CELE_F01G10.8
See related
AllianceGenome:WB:WBGene00000910
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific; I-SMAD binding activity; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including determination of adult lifespan; egg-laying behavior; and negative regulation of dauer larval development. Predicted to be part of heteromeric SMAD protein complex. Is expressed in several structures, including anal sphincter muscle; excretory duct cell; intestine; nerve ring; and phasmid sheath cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See daf-14 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10250627..10255852)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene transketolase Neighboring gene BPI2 domain-containing protein Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode Specific Peptide family, group D

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Caenorhabditis elegans dauer larva: developmental effects of pheromone, food, and temperature. Golden JW, et al. Dev Biol, 1984 Apr. PMID 6706004
  2. Chemosensory neurons function in parallel to mediate a pheromone response in C. elegans. Schackwitz WS, et al. Neuron, 1996 Oct. PMID 8893028
  3. Critical periods in the development of the Caenorhabditis elegans dauer larva. Swanson MM, et al. Dev Biol, 1981 May. PMID 7250500
  4. The DAF-3 Smad protein antagonizes TGF-beta-related receptor signaling in the Caenorhabditis elegans dauer pathway. Patterson GI, et al. Genes Dev, 1997 Oct 15. PMID 9334330, Free PMC Article
  5. A common muscarinic pathway for diapause recovery in the distantly related nematode species Caenorhabditis elegans and Ancylostoma caninum. Tissenbaum HA, et al. Proc Natl Acad Sci U S A, 2000 Jan 4. PMID 10618440, Free PMC Article

See all (83) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables I-SMAD binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in BMP signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in SMAD protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anatomical structure morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell differentiation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pigment accumulation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in pigment accumulation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic development IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of dauer larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of dauer larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of developmental process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of multicellular organismal process IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of heteromeric SMAD protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Smad-related protein daf-14
NP_001255475.1
  • Confirmed by transcript evidence
NP_001255476.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10250627..10255852
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268546.3 → NP_001255475.1  Smad-related protein daf-14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255475.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    F5GUE5, G5EEP2
    Conserved Domains (1) summary
    smart00524
    Location:133 → 308
    DWB; Domain B in dwarfin family proteins

  2. NM_001268547.2 → NP_001255476.1  Smad-related protein daf-14 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255476.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEP2
    Conserved Domains (1) summary
    smart00524
    Location:89 → 264
    DWB; Domain B in dwarfin family proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
F5GUE5.1

Gene LinkOut

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