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unc-43 Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;calcium/calmodulin-dependent protein kinase [ Caenorhabditis elegans ]

Gene ID: 177921, updated on 2-Nov-2024

Summary

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Official Symbol
unc-43
Official Full Name
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;calcium/calmodulin-dependent protein kinase
Primary source
WormBase:WBGene00006779
Locus tag
CELE_K11E8.1
See related
AllianceGenome:WB:WBGene00006779
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables calcium/calmodulin-dependent protein kinase activity; identical protein binding activity; and transmembrane transporter binding activity. Involved in MAPK cascade; medium-term memory; and positive regulation of gene expression. Acts upstream of or within serotonin biosynthetic process. Located in axon cytoplasm. Is expressed in several structures, including copulatory spicule; gonadal sheath cell; nervous system; oocyte; and postcloacal sensillum. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder; autosomal dominant intellectual developmental disorder 53; autosomal dominant intellectual developmental disorder 54; and autosomal recessive intellectual developmental disorder 63. Orthologous to several human genes including CAMK2D (calcium/calmodulin dependent protein kinase II delta). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See unc-43 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
24
Sequence:
Chromosome: IV; NC_003282.8 (10324254..10350217, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene LEDGF domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Tyrosine-protein kinase Neighboring gene SLC (SoLute Carrier) homolog Neighboring gene DH domain-containing protein;GON-4-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII. Stefan MI, et al. PLoS One, 2012. PMID 22279535, Free PMC Article
  2. Imaging single CaMKII holoenzymes at work by high-speed atomic force microscopy. Tsujioka S, et al. Sci Adv, 2023 Jun 30. PMID 37390213, Free PMC Article
  3. Dense core vesicle release: controlling the where as well as the when. Nurrish S. Genetics, 2014 Mar. PMID 24653208, Free PMC Article
  4. MAPK signaling and a mobile scaffold complex regulate AMPA receptor transport to modulate synaptic strength. Hoerndli FJ, et al. Cell Rep, 2022 Mar 29. PMID 35354038, Free PMC Article
  5. Intersubunit capture of regulatory segments is a component of cooperative CaMKII activation. Chao LH, et al. Nat Struct Mol Biol, 2010 Mar. PMID 20139983, Free PMC Article

See all (150) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans.
    Title: CaMKII mediates sexually dimorphic synaptic transmission at neuromuscular junctions in C. elegans.
  2. UNC-43/CaMKII-triggered anterograde signals recruit GABAARs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.
    Title: UNC-43/CaMKII-triggered anterograde signals recruit GABA(A)Rs to mediate inhibitory synaptic transmission and plasticity at C. elegans NMJs.
  3. MAPK signaling and a mobile scaffold complex regulate AMPA receptor transport to modulate synaptic strength.
    Title: MAPK signaling and a mobile scaffold complex regulate AMPA receptor transport to modulate synaptic strength.
  4. these data implicate the importance of subunit stoichiometry as another regulatory mechanism of PKA activity and lipid metabolism.
    Title: Protein Kinase A Subunit Balance Regulates Lipid Metabolism in Caenorhabditis elegans and Mammalian Adipocytes.
  5. Results with unc-43 mutants reveal a new function for CaM kinase II in blocking the regulated exocytosis of dense core vesicles before they are transported into axons.
    Title: A novel CaM kinase II pathway controls the location of neuropeptide release from Caenorhabditis elegans motor neurons.
  6. identified UNC-2/UNC-36 voltage-gated calcium channels and UNC-43/CaMKII as regulators of C. elegans synaptogenesis
    Title: The Caenorhabditis elegans voltage-gated calcium channel subunits UNC-2 and UNC-36 and the calcium-dependent kinase UNC-43/CaMKII regulate neuromuscular junction morphology.
  7. UNC-43 functions cell-autonomously in ADF neurons to generate training-dependent enhancement in neuronal activity and tph-1 transcription, and this cell-autonomous function of UNC-43 is required for learning.
    Title: A neuronal signaling pathway of CaMKII and Gqα regulates experience-dependent transcription of tph-1.
  8. Studies sugget the effect of CaMKII autophosphorylation at Thr286 on calmodulin trapping that it stabilises the active state and therefore makes the high-affinity binding site accessible.
    Title: Structural analysis and stochastic modelling suggest a mechanism for calmodulin trapping by CaMKII.
  9. The activity of egg-laying defective protein (EGL)-2 is promoted by calcium/calmodulin-dependent protein kinase II (CaMKII) unc-43.
    Title: The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males.
  10. Reuslts identify four genes to be required for the quercetin derived lifespan extension in C. elegans, namely age-1, daf-2, unc-43 and sek-1.
    Title: Quercetin mediated lifespan extension in Caenorhabditis elegans is modulated by age-1, daf-2, sek-1 and unc-43.
Submit: New GeneRIF Correction See all GeneRIFs (13)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables calcium/calmodulin-dependent protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium/calmodulin-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcium/calmodulin-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables calmodulin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calmodulin binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane transporter binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in MAPK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in MAPK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in medium-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of neuronal synaptic plasticity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of protein localization to plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within serotonin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in axon IEA
Inferred from Electronic Annotation
more info
  
located_in axon cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in neuron projection IDA
Inferred from Direct Assay
more info
 PubMed 
located_in perikaryon IEA
Inferred from Electronic Annotation
more info
  
is_active_in postsynaptic density IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein;Calcium/calmodulin-dependent protein kinase type II;calcium/calmodulin-dependent protein kinase
NP_001023293.2
  • Partially confirmed by transcript evidence
NP_001023298.1
  • Confirmed by transcript evidence
NP_001023304.1
  • Confirmed by transcript evidence
NP_001122788.1
  • Confirmed by transcript evidence
NP_001122789.1
  • Confirmed by transcript evidence
NP_001129863.1
  • Confirmed by transcript evidence
NP_001255480.1
  • Confirmed by transcript evidence
NP_001255481.1
  • Confirmed by transcript evidence
NP_001255482.1
  • Confirmed by transcript evidence
NP_001255483.1
  • Confirmed by transcript evidence
NP_001359633.1
  • Confirmed by transcript evidence
NP_001366992.1
  • Confirmed by transcript evidence
NP_001366993.1
  • Confirmed by transcript evidence
NP_001366994.1
  • Confirmed by transcript evidence
NP_001366996.1
  • Confirmed by transcript evidence
NP_001366997.1
  • Confirmed by transcript evidence
NP_001369918.1
  • Partially confirmed by transcript evidence
NP_001379280.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10324254..10350217 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028133.5 → NP_001023304.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023304.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:176 → 300
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  2. NM_001028122.5 → NP_001023293.2  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023293.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:97 → 221
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  3. NM_001380439.3 → NP_001366993.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd14086
    Location:10 → 300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:387 → 511
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  4. NM_001129317.5 → NP_001122789.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122789.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:136 → 260
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  5. NM_001028127.6 → NP_001023298.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001023298.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (3) summary
    smart00220
    Location:12 → 269
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd14086
    Location:10 → 300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:385 → 509
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  6. NM_001380442.1 → NP_001366992.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14086
    Location:10 → 300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

  7. NM_001129316.4 → NP_001122788.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122788.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:82 → 206
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  8. NM_001372918.3 → NP_001359633.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd14086
    Location:10 → 300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:400 → 524
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  9. NM_001392387.1 → NP_001379280.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd14086
    Location:10 → 300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:349 → 473
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  10. NM_001380440.3 → NP_001366994.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (2) summary
    cd14086
    Location:10 → 300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:438 → 562
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  11. NM_001268551.3 → NP_001255480.1  calcium/calmodulin-dependent protein kinase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255480.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDZ5
    Conserved Domains (2) summary
    cd14086
    Location:120 → 410
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II
    pfam08332
    Location:548 → 672
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  12. NM_001380441.3 → NP_001366996.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14086
    Location:10 → 298
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

  13. NM_001380443.1 → NP_001366997.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14086
    Location:10 → 300
    STKc_CaMKII; Catalytic domain of the Serine/Threonine kinase, Calcium/calmodulin-dependent protein kinase Type II

  14. NM_001268552.3 → NP_001255481.1  Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255481.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GUA8
    Conserved Domains (1) summary
    pfam08332
    Location:133 → 257
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  15. NM_001136391.4 → NP_001129863.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129863.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O62305
    Conserved Domains (1) summary
    pfam08332
    Location:83 → 207
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  16. NM_001268553.3 → NP_001255482.1  Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255482.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GUA9
    Conserved Domains (1) summary
    pfam08332
    Location:165 → 289
    CaMKII_AD; Calcium/calmodulin dependent protein kinase II association domain

  17. NM_001268554.3 → NP_001255483.1  Calcium/calmodulin-dependent protein kinase II association-domain domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001255483.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E7EM33
    Conserved Domains (1) summary
    cl09109
    Location:1 → 94
    NTF2_like; Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of ...

  18. NM_001383187.2 → NP_001369918.1  Calcium/calmodulin-dependent protein kinase type II [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cl21453
    Location:10 → 136
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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