sir-2.1 Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sir-2.1
Official Full Name: Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1
Primary source: WormBase:WBGene00004800
Locus tag: CELE_R11A8.4
See related: AllianceGenome:WB:WBGene00004800
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables deacetylase activity. Involved in dauer larval development; determination of adult lifespan; and intrinsic apoptotic signaling pathway in response to DNA damage. Located in chromosome, telomeric region; nucleus; and perinuclear region of cytoplasm. Is expressed in several structures, including intestinal cell; neurons; retrovesicular ganglion; tail; and ventral nerve cord. Used to study alcohol use disorder. Human ortholog(s) of this gene implicated in Huntington's disease and prostate cancer. Orthologous to human SIRT1 (sirtuin 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sir-2.1 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 7

Sequence:: Chromosome: IV; NC_003282.8 (10363318..10366229, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

metazoan SIRT1 orthologs as Hsp90 clients and reveal a novel crosstalk between the proteostasis and nutrient signaling networks, which may have implications in various age related diseases.
Title: Hsp90 Stabilizes SIRT1 Orthologs in Mammalian Cells and C. elegans.
SIRT1 plays essential roles in cell survival, inflammation, energy metabolism, and aging.
Title: The natural phytochemical dehydroabietic acid is an anti-aging reagent that mediates the direct activation of SIRT1.
The authors show that the mating circuits' functional durability depends on the metabolic regulator SIR-2.1, a NAD(+)-dependent histone deacetylase.
Title: SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male Caenorhabditis elegans.
Sir-2.1; dnj-14 double mutants showed full lifespan rescue by resveratrol.
Title: Caenorhabditis elegans dnj-14, the orthologue of the DNAJC5 gene mutated in adult onset neuronal ceroid lipofuscinosis, provides a new platform for neuroprotective drug screening and identifies a SIR-2.1-independent action of resveratrol.
Prolongation of survival under glucose exposure by quercetin is dependent on SIR-2.1, DAF-12, and MDT-15
Title: The polyphenol quercetin protects the mev-1 mutant of Caenorhabditis elegans from glucose-induced reduction of survival under heat-stress depending on SIR-2.1, DAF-12, and proteasomal activity.
C. elegans produces specific small molecules to control adult lifespan in a SIR-2.1-dependent manner.
Title: Pheromone sensing regulates Caenorhabditis elegans lifespan and stress resistance via the deacetylase SIR-2.1.
Overexpression of SIR2.1 protects neurons from mutant huntingtin toxicity.
Title: Integration of β-catenin, sirtuin, and FOXO signaling protects from mutant huntingtin toxicity.
caloric restriction increases the ability of heat shock to preserve movement in a polyglutamine toxicity neurodegenerative disease model and that this effect is dependent on sir2.1.
Title: Heat shock and caloric restriction have a synergistic effect on the heat shock response in a sir2.1-dependent manner in Caenorhabditis elegans.
calorie restriction affords, an sir-2.1 mediated, protection against the dopaminergic neurodegeneration, that might have implications for neurodegenerative Parkinson's disease.
Title: Sir-2.1 modulates 'calorie-restriction-mediated' prevention of neurodegeneration in Caenorhabditis elegans: implications for Parkinson's disease.
negative findings do not rule out a role for sirtuins in determination of metazoan lifespan, but they do cast doubt on the robustness of the previously reported effects of sirtuins on lifespan in C. elegans and Drosophila
Title: Absence of effects of Sir2 overexpression on lifespan in C. elegans and Drosophila.

Submit: New GeneRIF Correction See all GeneRIFs (21)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

R11A8.5 (e-PCR)
- UniSTS:311573

R11A8.4 (e-PCR)
- UniSTS:306344

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables NAD+ binding	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+ binding	IEA Inferred from Electronic Annotation more info
enables NAD-dependent histone deacetylase activity	IBA Inferred from Biological aspect of Ancestor more info
enables deacetylase activity	IDA Inferred from Direct Assay more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables p53 binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein lysine deacetylase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in intrinsic apoptotic signaling pathway in response to DNA damage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in chromosome, telomeric region	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
is_active_in nuclear inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in rDNA heterochromatin	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Deacetylase sirtuin-type domain-containing protein;NAD-dependent protein deacetylase sir-2.1

NP_001255484.1

Confirmed by transcript evidence

NP_001255485.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10363318..10366229 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001268555.5 → NP_001255484.1 NAD-dependent protein deacetylase sir-2.1 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255484.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q21921

Conserved Domains (1) summary

cd01408
Location:146 → 376

SIRT1; SIRT1: Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 ...
NM_001268556.3 → NP_001255485.1 Deacetylase sirtuin-type domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001255485.1

Status: REVIEWED

UniProtKB/TrEMBL

D3YT50

Conserved Domains (1) summary

cd01408
Location:116 → 346

SIRT1; Eukaryotic group (class1) which includes human sirtuins SIRT1-3 and yeast Hst1-4; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation. Sir2 proteins ...