tax-6 Serine/threonine-protein phosphatase 2B catalytic subunit [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: tax-6
Official Full Name: Serine/threonine-protein phosphatase 2B catalytic subunit
Primary source: WormBase:WBGene00006527
Locus tag: CELE_C02F4.2
See related: AllianceGenome:WB:WBGene00006527
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables calcium ion binding activity and calmodulin-dependent protein phosphatase activity. Involved in several processes, including determination of adult lifespan; male mating behavior; and olfactory learning. Located in several cellular components, including dendrite; neuronal cell body; and non-motile cilium. Is expressed in several structures, including germ line; hypodermis; muscle cell; and nervous system. Human ortholog(s) of this gene implicated in aortic valve stenosis; developmental and epileptic encephalopathy 91; and schizophrenia. Orthologous to several human genes including PPP3CB (protein phosphatase 3 catalytic subunit beta) and PPP3CC (protein phosphatase 3 catalytic subunit gamma). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tax-6 in Genome Data Viewer

Location:: chromosome: IV

Exon count:: 15

Sequence:: Chromosome: IV; NC_003282.8 (10492869..10501600, complement)

Chromosome IV - NC_003282.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CNP-1 interacts with the catalytic domain of the C. elegans calcineurin A subunit, TAX-6 and is dephosphorylated by TAX-6
Title: CNP-1 (ARRD-17), a novel substrate of calcineurin, is critical for modulation of egg-laying and locomotion in response to food and lysine sensation in Caenorhabditis elegans.
Maintenance of swimming requires the protein phosphatase calcineurin homolog tax-6 activity in the sensory neurons.
Title: Calcineurin and protein kinase G regulate C. elegans behavioral quiescence during locomotion in liquid.
hlh-11 may function to regulate serotonin-mediated egg laying at the downstream of tax-6.
Title: Identification and characterization of a putative basic helix-loop-helix (bHLH) transcription factor interacting with calcineurin in C. elegans.
tax-6 encodes the catalytic subunit of calcineurin and is ubiquitously expressed at all developmental stages.
Title: Opposing functions of calcineurin and CaMKII regulate G-protein signaling in egg-laying behavior of C.elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

C02F4.2 (e-PCR)
- UniSTS:308892

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables calcium ion binding	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables calmodulin-dependent protein phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables calmodulin-dependent protein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin-dependent protein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in behavior	IEA Inferred from Electronic Annotation more info
involved_in calcineurin-mediated signaling	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcineurin-mediated signaling	IEA Inferred from Electronic Annotation more info
involved_in calcium-mediated signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chemotaxis	IEA Inferred from Electronic Annotation more info
involved_in chemotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in dauer larval development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in determination of adult lifespan	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in endocytosis	IEA Inferred from Electronic Annotation more info
involved_in hyperosmotic response	IGI Inferred from Genetic Interaction more info	PubMed
involved_in hyperosmotic response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in olfactory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in olfactory learning	IGI Inferred from Genetic Interaction more info	PubMed
involved_in olfactory learning	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein localization to non-motile cilium	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to alkaline pH	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hermaphrodite contact	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermosensory behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermosensory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in thermotaxis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in thermotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in vulval location	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
part_of calcineurin complex	IBA Inferred from Biological aspect of Ancestor more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cilium	IEA Inferred from Electronic Annotation more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in dendrite	IDA Inferred from Direct Assay more info	PubMed
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in neuronal cell body	IDA Inferred from Direct Assay more info	PubMed
located_in non-motile cilium	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in perikaryon	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine-protein phosphatase 2B catalytic subunit

NP_001076658.2

Confirmed by transcript evidence

NP_001367052.1

Partially confirmed by transcript evidence

NP_001379183.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003282.8 Reference assembly

Range

10492869..10501600 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001083189.5 → NP_001076658.2 Serine/threonine-protein phosphatase 2B catalytic subunit [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001076658.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q0G819, Q86MD4, Q95002

Conserved Domains (2) summary

smart00156
Location:83 → 354

PP2Ac; Protein phosphatase 2A homologues, catalytic domain

cd07416
Location:66 → 370

MPP_PP2B; PP2B, metallophosphatase domain
NM_001392391.1 → NP_001379183.1 Serine/threonine-protein phosphatase 2B catalytic subunit [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd07416
Location:66 → 370

MPP_PP2B; PP2B, metallophosphatase domain
NM_001380448.1 → NP_001367052.1 Serine/threonine-protein phosphatase 2B catalytic subunit [Caenorhabditis elegans]

Status: REVIEWED

Conserved Domains (1) summary

cd07416
Location:66 → 370

MPP_PP2B; PP2B, metallophosphatase domain