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fic-1 Protein adenylyltransferase fic-1 [ Caenorhabditis elegans ]

Gene ID: 177990, updated on 2-Nov-2024

Summary

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Official Symbol
fic-1
Official Full Name
Protein adenylyltransferase fic-1
Primary source
WormBase:WBGene00014004
Locus tag
CELE_ZK593.8
See related
AllianceGenome:WB:WBGene00014004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables AMPylase activity. Involved in defense response to Gram-negative bacterium. Located in endoplasmic reticulum and nuclear envelope. Is expressed widely. Orthologous to human FICD (FIC domain protein adenylyltransferase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fic-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
6
Sequence:
Chromosome: IV; NC_003282.8 (10937454..10939934)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Sm domain-containing protein Neighboring gene Protein lgg;Protein lgg-2 Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Over-expression of the constitutive AMPylase FIC-1(E274G) does not deplete cellular ATP pools in C. elegans. Champion M, et al. MicroPubl Biol, 2021 Jun 25. PMID 34189425, Free PMC Article
  2. Unrestrained AMPylation targets cytosolic chaperones and activates the heat shock response. Truttmann MC, et al. Proc Natl Acad Sci U S A, 2017 Jan 10. PMID 28031489, Free PMC Article
  3. The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones. Truttmann MC, et al. PLoS Genet, 2016 May. PMID 27138431, Free PMC Article
  4. The AMPylase FIC-1 modulates TGF-β signaling in Caenorhabditis elegans. Hernandez-Lima MA, et al. Front Mol Neurosci, 2022. PMID 36504677, Free PMC Article
  5. Delayed development and lifespan extension as features of metabolic lifestyle alteration in C. elegans under dietary restriction. Szewczyk NJ, et al. J Exp Biol, 2006 Oct. PMID 17023606

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. We identify a link between FIC-1-mediated AMPylation and susceptibility to the pathogen Pseudomonas aeruginosa, establishing a connection between AMPylation and innate immunity in C. elegans
    Title: The Caenorhabditis elegans Protein FIC-1 Is an AMPylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables AMPylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables AMPylase activity IEA
Inferred from Electronic Annotation
more info
  
enables AMPylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nuclear membrane IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein adenylyltransferase fic-1
NP_502036.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10937454..10939934
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069635.6 → NP_502036.1  Protein adenylyltransferase fic-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502036.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q23544
    Conserved Domains (4) summary
    COG3177
    Location:265 → 478
    COG3177; Fic family protein [Transcription]
    sd00006
    Location:180 → 210
    TPR; TPR repeat [structural motif]
    pfam02661
    Location:326 → 422
    Fic; Fic/DOC family
    pfam13414
    Location:146 → 212
    TPR_11; TPR repeat
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q23544.2

Gene LinkOut

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