U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

cyb-2.1 G2/mitotic-specific cyclin-B [ Caenorhabditis elegans ]

Gene ID: 177994, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
cyb-2.1
Official Full Name
G2/mitotic-specific cyclin-B
Primary source
WormBase:WBGene00000866
Locus tag
CELE_Y43E12A.1
See related
AllianceGenome:WB:WBGene00000866
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Involved in anterior/posterior axis specification, embryo and oocyte maturation. Predicted to be part of cyclin-dependent protein kinase holoenzyme complex. Predicted to be active in cytoplasm; microtubule organizing center; and nucleus. Is expressed in germ line. Used to study cardiovascular system disease. Human ortholog(s) of this gene implicated in breast cancer and prostate cancer. Orthologous to several human genes including CCNB1 (cyclin B1). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See cyb-2.1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
4
Sequence:
Chromosome: IV; NC_003282.8 (10985985..10987426)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene 3CxxC-type domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. C. elegans mitotic cyclins have distinct as well as overlapping functions in chromosome segregation. van der Voet M, et al. Cell Cycle, 2009 Dec 15. PMID 19829076, Free PMC Article
  2. The ubiquitin ligase CRL2ZYG11 targets cyclin B1 for degradation in a conserved pathway that facilitates mitotic slippage. Balachandran RS, et al. J Cell Biol, 2016 Oct 24. PMID 27810909, Free PMC Article
  3. CDK-1 and two B-type cyclins promote PAR-6 stabilization during polarization of the early C. elegans embryo. Rabilotta A, et al. PLoS One, 2015. PMID 25658117, Free PMC Article
  4. The C. elegans Myt1 ortholog is required for the proper timing of oocyte maturation. Burrows AE, et al. Development, 2006 Feb. PMID 16421191, Free PMC Article
  5. DPL-1 (DP) acts in the germ line to coordinate ovulation and fertilization in C. elegans. Chi W, et al. Mech Dev, 2009 May-Jun. PMID 19368797, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in anterior/posterior axis specification, embryo IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in oocyte maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
G2/mitotic-specific cyclin-B
NP_502047.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    10985985..10987426
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069646.8 → NP_502047.1  G2/mitotic-specific cyclin-B [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502047.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45926
    Conserved Domains (2) summary
    COG5024
    Location:32 → 300
    COG5024; Cyclin [Cell division and chromosome partitioning]
    pfam00134
    Location:34 → 159
    Cyclin_N; Cyclin, N-terminal domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.