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mogs-1 Mannosyl-oligosaccharide glucosidase [ Caenorhabditis elegans ]

Gene ID: 177998, updated on 2-Nov-2024

Summary

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Official Symbol
mogs-1
Official Full Name
Mannosyl-oligosaccharide glucosidase
Primary source
WormBase:WBGene00008775
Locus tag
CELE_F13H10.4
See related
AllianceGenome:WB:WBGene00008775
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable Glc3Man9GlcNAc2 oligosaccharide glucosidase activity. Predicted to be involved in protein N-linked glycosylation. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIb. Orthologous to human MOGS (mannosyl-oligosaccharide glucosidase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mogs-1 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
9
Sequence:
Chromosome: IV; NC_003282.8 (11016224..11021670, complement)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Cysteine-rich transmembrane CYSTM domain-containing protein Neighboring gene NAD(+) diphosphatase;NAD-capped RNA hydrolase ndx-9 Neighboring gene Amino acid transporter transmembrane domain-containing protein;Sodium-coupled neutral amino acid transporter 9 homolog Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC transporter permease;Small subunit of serine palmitoyltransferase Neighboring gene 10-formyltetrahydrofolate dehydrogenase Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Deficiency of α-glucosidase I alters glycoprotein glycosylation and lifespan in Caenorhabditis elegans. Katoh T, et al. Glycobiology, 2013 Oct. PMID 23836288, Free PMC Article
  2. Gut commensal E. coli outer membrane proteins activate the host food digestive system through neural-immune communication. Geng S, et al. Cell Host Microbe, 2022 Oct 12. PMID 36057258
  3. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  4. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  5. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables Glc3Man9GlcNAc2 oligosaccharide glucosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in oligosaccharide metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein N-linked glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mannosyl-oligosaccharide glucosidase
NP_001076681.1
  • Confirmed by transcript evidence
NP_001076682.1
  • Confirmed by transcript evidence
NP_001122771.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11016224..11021670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001083213.5 → NP_001076682.1  Mannosyl-oligosaccharide glucosidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076682.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19426
    Conserved Domains (2) summary
    pfam03200
    Location:303 → 785
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:82 → 246
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

  2. NM_001083212.4 → NP_001076681.1  Mannosyl-oligosaccharide glucosidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001076681.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A5JYS7, Q0G829, Q0G830, Q19426
    Conserved Domains (2) summary
    pfam03200
    Location:310 → 792
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:89 → 253
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain

  3. NM_001129299.5 → NP_001122771.1  Mannosyl-oligosaccharide glucosidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001122771.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q19426
    Conserved Domains (2) summary
    pfam03200
    Location:306 → 788
    Glyco_hydro_63; Glycosyl hydrolase family 63 C-terminal domain
    pfam16923
    Location:82 → 246
    Glyco_hydro_63N; Glycosyl hydrolase family 63 N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q19426.2

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