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alh-3 10-formyltetrahydrofolate dehydrogenase [ Caenorhabditis elegans ]

Gene ID: 177999, updated on 2-Nov-2024

Summary

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Official Symbol
alh-3
Official Full Name
10-formyltetrahydrofolate dehydrogenase
Primary source
WormBase:WBGene00000109
Locus tag
CELE_F36H1.6
See related
AllianceGenome:WB:WBGene00000109
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable aldehyde dehydrogenase (NAD+) activity and formyltetrahydrofolate dehydrogenase activity. Predicted to be involved in 10-formyltetrahydrofolate catabolic process; biosynthetic process; and one-carbon metabolic process. Predicted to be located in cytoplasm. Orthologous to human ALDH1L1 (aldehyde dehydrogenase 1 family member L1) and ALDH1L2 (aldehyde dehydrogenase 1 family member L2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See alh-3 in Genome Data Viewer
Location:
chromosome: IV
Exon count:
7
Sequence:
Chromosome: IV; NC_003282.8 (11022603..11025870)

Chromosome IV - NC_003282.8Genomic Context describing neighboring genes Neighboring gene Mannosyl-oligosaccharide glucosidase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ABC transporter permease;Small subunit of serine palmitoyltransferase Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003282.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional genomic analysis identifies miRNA repertoire regulating C. elegans oocyte development. Minogue AL, et al. Nat Commun, 2018 Dec 14. PMID 30552320, Free PMC Article
  2. The conserved miR-51 microRNA family is redundantly required for embryonic development and pharynx attachment in Caenorhabditis elegans. Shaw WR, et al. Genetics, 2010 Jul. PMID 20421599, Free PMC Article
  3. Most Caenorhabditis elegans microRNAs are individually not essential for development or viability. Miska EA, et al. PLoS Genet, 2007 Dec. PMID 18085825, Free PMC Article
  4. Many families of C. elegans microRNAs are not essential for development or viability. Alvarez-Saavedra E, et al. Curr Biol, 2010 Feb 23. PMID 20096582, Free PMC Article
  5. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aldehyde dehydrogenase (NAD+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables formyltetrahydrofolate dehydrogenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables formyltetrahydrofolate dehydrogenase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 10-formyltetrahydrofolate catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in one-carbon metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
10-formyltetrahydrofolate dehydrogenase
NP_502054.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003282.8 Reference assembly

    Range
    11022603..11025870
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_069653.9 → NP_502054.2  10-formyltetrahydrofolate dehydrogenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_502054.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECV9
    Conserved Domains (5) summary
    cd08647
    Location:1 → 209
    FMT_core_FDH_N; 10-formyltetrahydrofolate dehydrogenase (FDH), N-terminal hydrolase domain
    cd08703
    Location:214 → 315
    FDH_Hydrolase_C; The C-terminal subdomain of the hydrolase domain on the bi-functional protein 10-formyltetrahydrofolate dehydrogenase
    TIGR00460
    Location:1 → 318
    fmt; methionyl-tRNA formyltransferase
    pfam00550
    Location:335 → 393
    PP-binding; Phosphopantetheine attachment site
    cl11961
    Location:423 → 908
    ALDH-SF; NAD(P)+-dependent aldehyde dehydrogenase superfamily
Nucleotide Protein
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